Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose

Controlling inflammation is critical for preventing many diseases including cancer, autoimmune disorders and hypersensitivity reactions. NF-E2-related factor 2 (Nrf2) is a key transcription factor that controls the cellular antioxidant and cytoprotective response. Moreover, Nrf2 has been implicated...

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Detalles Bibliográficos
Autores principales: Muri, Jonathan, Wolleb, Helene, Broz, Petr, Carreira, Erick M., Kopf, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387846/
https://www.ncbi.nlm.nih.gov/pubmed/32863237
http://dx.doi.org/10.1016/j.redox.2020.101647

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387846/
https://www.ncbi.nlm.nih.gov/pubmed/32863237
http://dx.doi.org/10.1016/j.redox.2020.101647

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