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Bitter Taste Receptor Antagonists Inhibit the Bitter taste of Canola Meal Extract in Chickens

Canola meal (CM) is a commonly used feedstuff; however, it is known to be bitter, and chickens have a low preference for it. The purpose of this study was to seek clarity regarding the taste quality of CM and find methods to increase the preference for CM by chickens. We examined whether CM activate...

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Autores principales: Kawabata, Fuminori, Dey, Bapon, Yoshida, Yuta, Nishimura, Shotaro, Tabata, Shoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Poultry Science Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387948/
https://www.ncbi.nlm.nih.gov/pubmed/32733156
http://dx.doi.org/10.2141/jpsa.0190099
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author Kawabata, Fuminori
Dey, Bapon
Yoshida, Yuta
Nishimura, Shotaro
Tabata, Shoji
author_facet Kawabata, Fuminori
Dey, Bapon
Yoshida, Yuta
Nishimura, Shotaro
Tabata, Shoji
author_sort Kawabata, Fuminori
collection PubMed
description Canola meal (CM) is a commonly used feedstuff; however, it is known to be bitter, and chickens have a low preference for it. The purpose of this study was to seek clarity regarding the taste quality of CM and find methods to increase the preference for CM by chickens. We examined whether CM activates the bitter taste receptors in chickens, whether chickens show aversive responses to CM, and whether an antagonist for bitter taste receptors inhibits the bitterness of CM. Using the Ca(2+) imaging technique, we showed that CM contains bitter compounds, which activate the bitter taste receptors in chickens. Further, we showed that 6-methoxyflavanone (6-meth), an antagonist for the bitter taste receptors in chickens, inhibits the activation of these receptors by CM extract. Although chickens showed a low preference for the solution of the CM extract, their preference was improved by adding 6-meth in behavioral tests. These results suggest that the preference for CM could be improved by inhibiting the bitter taste receptors in chickens.
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spelling pubmed-73879482020-07-29 Bitter Taste Receptor Antagonists Inhibit the Bitter taste of Canola Meal Extract in Chickens Kawabata, Fuminori Dey, Bapon Yoshida, Yuta Nishimura, Shotaro Tabata, Shoji J Poult Sci Full Papers Canola meal (CM) is a commonly used feedstuff; however, it is known to be bitter, and chickens have a low preference for it. The purpose of this study was to seek clarity regarding the taste quality of CM and find methods to increase the preference for CM by chickens. We examined whether CM activates the bitter taste receptors in chickens, whether chickens show aversive responses to CM, and whether an antagonist for bitter taste receptors inhibits the bitterness of CM. Using the Ca(2+) imaging technique, we showed that CM contains bitter compounds, which activate the bitter taste receptors in chickens. Further, we showed that 6-methoxyflavanone (6-meth), an antagonist for the bitter taste receptors in chickens, inhibits the activation of these receptors by CM extract. Although chickens showed a low preference for the solution of the CM extract, their preference was improved by adding 6-meth in behavioral tests. These results suggest that the preference for CM could be improved by inhibiting the bitter taste receptors in chickens. Japan Poultry Science Association 2020-07-25 /pmc/articles/PMC7387948/ /pubmed/32733156 http://dx.doi.org/10.2141/jpsa.0190099 Text en 2020, Japan Poultry Science Association. The Journal of Poultry Science is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Full Papers
Kawabata, Fuminori
Dey, Bapon
Yoshida, Yuta
Nishimura, Shotaro
Tabata, Shoji
Bitter Taste Receptor Antagonists Inhibit the Bitter taste of Canola Meal Extract in Chickens
title Bitter Taste Receptor Antagonists Inhibit the Bitter taste of Canola Meal Extract in Chickens
title_full Bitter Taste Receptor Antagonists Inhibit the Bitter taste of Canola Meal Extract in Chickens
title_fullStr Bitter Taste Receptor Antagonists Inhibit the Bitter taste of Canola Meal Extract in Chickens
title_full_unstemmed Bitter Taste Receptor Antagonists Inhibit the Bitter taste of Canola Meal Extract in Chickens
title_short Bitter Taste Receptor Antagonists Inhibit the Bitter taste of Canola Meal Extract in Chickens
title_sort bitter taste receptor antagonists inhibit the bitter taste of canola meal extract in chickens
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387948/
https://www.ncbi.nlm.nih.gov/pubmed/32733156
http://dx.doi.org/10.2141/jpsa.0190099
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