Cargando…

Comparison of Sleep Quality before and after Chemotherapy in Locally Advanced Nonsmall Cell Lung Cancer Patients: A Prospective Study

BACKGROUND: Preservation of sleep quality is a modifiable and treatable factor, which may enhance the patient's adherence to other supportive and palliative care procedures. The outcome of sleep disturbances in lung cancer patients before and after treatment aren't reported. The aim of thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Belloumi, N., Maalej Bellaj, S., Bachouche, I., Chermiti Ben Abdallah, F., Fenniche, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387987/
https://www.ncbi.nlm.nih.gov/pubmed/32765910
http://dx.doi.org/10.1155/2020/8235238
_version_ 1783564230036815872
author Belloumi, N.
Maalej Bellaj, S.
Bachouche, I.
Chermiti Ben Abdallah, F.
Fenniche, S.
author_facet Belloumi, N.
Maalej Bellaj, S.
Bachouche, I.
Chermiti Ben Abdallah, F.
Fenniche, S.
author_sort Belloumi, N.
collection PubMed
description BACKGROUND: Preservation of sleep quality is a modifiable and treatable factor, which may enhance the patient's adherence to other supportive and palliative care procedures. The outcome of sleep disturbances in lung cancer patients before and after treatment aren't reported. The aim of this study was to investigate changes in sleep quality before and after chemotherapy in locally advanced or metastatic NSCLC patients. METHODS: It was a prospective study including 64 patients with stage III or IV nonsmall-cell lung cancer. Patients answered the Tunisian dialectal version of the following questionnaires: PSQI and QLQ-C30 in order to evaluate, respectively, the sleep quality and the quality of life. The assessments took place before chemotherapy and then repeated after the chemotherapy course was over. RESULTS: The mean age was 62.9 years. All patients were active smokers. Before chemotherapy, there were 10 patients (15%) with poor sleep quality. The most frequent complaints were daytime sleepiness (70%) and nocturnal arousals (100%). After chemotherapy, the mean PSQI score increased from 2.9 to 5.4, and 45% of all patients had poor sleep quality. Most frequent complaints were the extension of sleep latency (69%), daytime sleepiness (98%), and nocturnal arousals (100%). Predicting factors of sleep disturbance according to statistical univariate analysis were delayed diagnosis confirmation (p = 0.05), delayed treatment onset (p < 10(−3)), depressive mood (p = 0.001), and anxious mood (p = 0.001). Multivariate analysis had shown a significant and independent correlation between sleep quality and shortened diagnosis and treatment delays. Sociodemographic parameters, clinical parameters, and factors related to treatment procedure had no correlation with sleep quality. CONCLUSIONS: Our study demonstrates the persistence and potential intensity worsening of sleep disturbances in advanced stage nonsmall-cell lung cancer patients. We, hereby, reported a statistical correlation between sleep quality and quality of life in our patients.
format Online
Article
Text
id pubmed-7387987
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-73879872020-08-05 Comparison of Sleep Quality before and after Chemotherapy in Locally Advanced Nonsmall Cell Lung Cancer Patients: A Prospective Study Belloumi, N. Maalej Bellaj, S. Bachouche, I. Chermiti Ben Abdallah, F. Fenniche, S. Sleep Disord Research Article BACKGROUND: Preservation of sleep quality is a modifiable and treatable factor, which may enhance the patient's adherence to other supportive and palliative care procedures. The outcome of sleep disturbances in lung cancer patients before and after treatment aren't reported. The aim of this study was to investigate changes in sleep quality before and after chemotherapy in locally advanced or metastatic NSCLC patients. METHODS: It was a prospective study including 64 patients with stage III or IV nonsmall-cell lung cancer. Patients answered the Tunisian dialectal version of the following questionnaires: PSQI and QLQ-C30 in order to evaluate, respectively, the sleep quality and the quality of life. The assessments took place before chemotherapy and then repeated after the chemotherapy course was over. RESULTS: The mean age was 62.9 years. All patients were active smokers. Before chemotherapy, there were 10 patients (15%) with poor sleep quality. The most frequent complaints were daytime sleepiness (70%) and nocturnal arousals (100%). After chemotherapy, the mean PSQI score increased from 2.9 to 5.4, and 45% of all patients had poor sleep quality. Most frequent complaints were the extension of sleep latency (69%), daytime sleepiness (98%), and nocturnal arousals (100%). Predicting factors of sleep disturbance according to statistical univariate analysis were delayed diagnosis confirmation (p = 0.05), delayed treatment onset (p < 10(−3)), depressive mood (p = 0.001), and anxious mood (p = 0.001). Multivariate analysis had shown a significant and independent correlation between sleep quality and shortened diagnosis and treatment delays. Sociodemographic parameters, clinical parameters, and factors related to treatment procedure had no correlation with sleep quality. CONCLUSIONS: Our study demonstrates the persistence and potential intensity worsening of sleep disturbances in advanced stage nonsmall-cell lung cancer patients. We, hereby, reported a statistical correlation between sleep quality and quality of life in our patients. Hindawi 2020-06-30 /pmc/articles/PMC7387987/ /pubmed/32765910 http://dx.doi.org/10.1155/2020/8235238 Text en Copyright © 2020 N. Belloumi et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Belloumi, N.
Maalej Bellaj, S.
Bachouche, I.
Chermiti Ben Abdallah, F.
Fenniche, S.
Comparison of Sleep Quality before and after Chemotherapy in Locally Advanced Nonsmall Cell Lung Cancer Patients: A Prospective Study
title Comparison of Sleep Quality before and after Chemotherapy in Locally Advanced Nonsmall Cell Lung Cancer Patients: A Prospective Study
title_full Comparison of Sleep Quality before and after Chemotherapy in Locally Advanced Nonsmall Cell Lung Cancer Patients: A Prospective Study
title_fullStr Comparison of Sleep Quality before and after Chemotherapy in Locally Advanced Nonsmall Cell Lung Cancer Patients: A Prospective Study
title_full_unstemmed Comparison of Sleep Quality before and after Chemotherapy in Locally Advanced Nonsmall Cell Lung Cancer Patients: A Prospective Study
title_short Comparison of Sleep Quality before and after Chemotherapy in Locally Advanced Nonsmall Cell Lung Cancer Patients: A Prospective Study
title_sort comparison of sleep quality before and after chemotherapy in locally advanced nonsmall cell lung cancer patients: a prospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387987/
https://www.ncbi.nlm.nih.gov/pubmed/32765910
http://dx.doi.org/10.1155/2020/8235238
work_keys_str_mv AT belloumin comparisonofsleepqualitybeforeandafterchemotherapyinlocallyadvancednonsmallcelllungcancerpatientsaprospectivestudy
AT maalejbellajs comparisonofsleepqualitybeforeandafterchemotherapyinlocallyadvancednonsmallcelllungcancerpatientsaprospectivestudy
AT bachouchei comparisonofsleepqualitybeforeandafterchemotherapyinlocallyadvancednonsmallcelllungcancerpatientsaprospectivestudy
AT chermitibenabdallahf comparisonofsleepqualitybeforeandafterchemotherapyinlocallyadvancednonsmallcelllungcancerpatientsaprospectivestudy
AT fenniches comparisonofsleepqualitybeforeandafterchemotherapyinlocallyadvancednonsmallcelllungcancerpatientsaprospectivestudy