Cargando…

Upregulation of CENPM facilitates tumor metastasis via the mTOR/p70S6K signaling pathway in pancreatic cancer

Pancreatic cancer is a severe disease with high morbidity and mortality. However, the primary molecular mechanisms of pancreatic tumor formation and progression remain unclear. The present study using sequencing technology revealed that the centromere protein M (CENPM) gene was overexpressed in panc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Chenlei, Zhang, Tan, Li, Ding, Huang, Chongchu, Tang, Hengjie, Ni, Xiao-Feng, Chen, Bicheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388243/ https://www.ncbi.nlm.nih.gov/pubmed/32705259 http://dx.doi.org/10.3892/or.2020.7673

Ejemplares similares

Upregulation of CENPM facilitates lung adenocarcinoma progression via PI3K/AKT/mTOR signaling pathway: CENPM promotes lung adenocarcinoma progression
por: Liu, Chao, et al.
Publicado: (2021)

Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling
por: Ni, Fubiao, et al.
Publicado: (2019)

KRT17 Functions as a Tumor Promoter and Regulates Proliferation, Migration and Invasion in Pancreatic Cancer via mTOR/S6k1 Pathway
por: Li, Ding, et al.
Publicado: (2020)

Upregulation of CENPM promotes hepatocarcinogenesis through mutiple mechanisms
por: Xiao, Yusha, et al.
Publicado: (2019)

Adipose-derived mesenchymal stem cells ameliorate dibutyltin dichloride-induced chronic pancreatitis by inhibiting the PI3K/AKT/mTOR signaling pathway
por: Xu, Xiangxiang, et al.
Publicado: (2020)

Upregulation of CENPM is associated with poor clinical outcome and suppression of immune profile in clear cell renal cell carcinoma
por: Zhang, Zhi-Cheng, et al.
Publicado: (2023)

Expression of mTOR/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol intervention
por: Tang, Zhi-Ming, et al.
Publicado: (2017)

Periplocin inhibits the growth of pancreatic cancer by inducing apoptosis via AMPK‐mTOR signaling
por: Xie, Gangyin, et al.
Publicado: (2020)

Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes
por: Xu, Jing, et al.
Publicado: (2020)

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer
por: Heinonen, Henna, et al.
Publicado: (2008)

Islet Transplantation Attenuating Testicular Injury in Type 1 Diabetic Rats Is Associated with Suppression of Oxidative Stress and Inflammation via Nrf-2/HO-1 and NF-κB Pathways
por: Zhu, Xiandong, et al.
Publicado: (2019)

Human umbilical cord–derived mesenchymal stem cells improve chronic pancreatitis in rats via the AKT-mTOR-S6K1 signaling pathway
por: Kong, Lijun, et al.
Publicado: (2021)

Radiofrequency ablation in combination with an mTOR inhibitor restrains pancreatic cancer growth induced by intrinsic HSP70
por: Gao, Shanshan, et al.
Publicado: (2020)

Human Positive Coactivator 4 Affects the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma via the mTOR/P70s6k Signaling Pathway
por: Su, Xingxing, et al.
Publicado: (2020)

Inhibition of TRIM32 by ibr‐7 treatment sensitizes pancreatic cancer cells to gemcitabine via mTOR/p70S6K pathway
por: Zhang, Bo, et al.
Publicado: (2021)

Erianthridin suppresses non-small-cell lung cancer cell metastasis through inhibition of Akt/mTOR/p70(S6K) signaling pathway
por: Pothongsrisit, Sutthaorn, et al.
Publicado: (2021)

Autophagy activated by tuberin/mTOR/p70S6K suppression is a protective mechanism against local anaesthetics neurotoxicity
por: Xiong, Jingwei, et al.
Publicado: (2016)

Periplocin Induces Apoptosis of Pancreatic Cancer Cells through Autophagy via the AMPK/mTOR Pathway
por: Zhang, Hewei, et al.
Publicado: (2022)

TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells
por: Yang, Chen, et al.
Publicado: (2021)

Targeting mTOR dependency in pancreatic cancer
por: Morran, Douglas C, et al.
Publicado: (2014)

Targeting mTOR in Pancreatic Ductal Adenocarcinoma
por: Iriana, Sentia, et al.
Publicado: (2016)

AKT/mTOR substrate P70S6K is frequently phosphorylated in gallbladder cancer tissue and cell lines
por: Leal, Pamela, et al.
Publicado: (2013)

The mTOR/p70S6K1 signaling pathway in renal fibrosis of children with immunoglobulin A nephropathy
por: Xu, Yuanyuan, et al.
Publicado: (2017)

Puerarin inhibits bladder cancer cell proliferation through the mTOR/p70S6K signaling pathway
por: Jiang, Kehua, et al.
Publicado: (2018)

MECP2 Mutation Interrupts Nucleolin–mTOR–P70S6K Signaling in Rett Syndrome Patients
por: Olson, Carl O., et al.
Publicado: (2018)

Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells
por: Lan, Chieh-Yu, et al.
Publicado: (2019)

Rapamycin Attenuated Zinc-Induced Tau Phosphorylation and Oxidative Stress in Rats: Involvement of Dual mTOR/p70S6K and Nrf2/HO-1 Pathways
por: Lai, Chencen, et al.
Publicado: (2022)

High CENPM mRNA expression and its prognostic significance in hepatocellular carcinoma: a study based on data mining
por: Wu, Zeng-hong, et al.
Publicado: (2020)

PI3K/AKT/mTOR/p70S6K Pathway Is Involved in Aβ25-35-Induced Autophagy
por: Fan, Shengnuo, et al.
Publicado: (2015)

Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway
por: Li, Jie, et al.
Publicado: (2019)

Upregulated TRIM29 promotes proliferation and metastasis of nasopharyngeal carcinoma via PTEN/AKT/mTOR signal pathway
por: Zhou, Xiao-Min, et al.
Publicado: (2016)

Cordycepin inhibits cell senescence by ameliorating lysosomal dysfunction and inducing autophagy through the AMPK and mTOR–p70S6K pathway
por: Zuo, Shi Qi, et al.
Publicado: (2021)

The VEGF pathway and the AKT/mTOR/p70S6K1 signalling pathway in human epithelial ovarian cancer
por: Trinh, X B, et al.
Publicado: (2009)

The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray
por: Xiao, Li, et al.
Publicado: (2009)

Carnosine Inhibits the Proliferation of Human Gastric Carcinoma Cells by Retarding Akt/mTOR/p70S6K Signaling
por: Zhang, Zhenwei, et al.
Publicado: (2014)

Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR/p70s6k pathway
por: Yang, Baojun, et al.
Publicado: (2017)

Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling
por: Dou, Ning, et al.
Publicado: (2016)

Effects of bufalin on the mTOR/p70S6K pathway and apoptosis in esophageal squamous cell carcinoma in nude mice
por: Liu, Yao, et al.
Publicado: (2017)

Effects of Akt/mTOR/p70S6K Signaling Pathway Regulation on Neuron Remodeling Caused by Translocation Repair
por: Yuan, Yusong, et al.
Publicado: (2020)

Everolimus and mTOR inhibition in pancreatic neuroendocrine tumors
por: Yim, Kein-Leong
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_o5oegejp584f2diep2mul29r3o