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The skin microbiome in psoriatic disease: A systematic review and critical appraisal

BACKGROUND: Psoriasis affects 1–3% of the Canadian population. Psoriatic arthritis (PsA), the most common comorbidity of psoriasis, affects up to 30% of psoriasis patients. The skin microbiome is hypothesized to play a role in the pathogenesis of psoriatic disease (PsD-psoriasis and PsA). OBJECTIVE:...

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Autores principales: Yerushalmi, Meital, Elalouf, Ofir, Anderson, Melanie, Chandran, Vinod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388378/
https://www.ncbi.nlm.nih.gov/pubmed/32743498
http://dx.doi.org/10.1016/j.jtauto.2019.100009
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author Yerushalmi, Meital
Elalouf, Ofir
Anderson, Melanie
Chandran, Vinod
author_facet Yerushalmi, Meital
Elalouf, Ofir
Anderson, Melanie
Chandran, Vinod
author_sort Yerushalmi, Meital
collection PubMed
description BACKGROUND: Psoriasis affects 1–3% of the Canadian population. Psoriatic arthritis (PsA), the most common comorbidity of psoriasis, affects up to 30% of psoriasis patients. The skin microbiome is hypothesized to play a role in the pathogenesis of psoriatic disease (PsD-psoriasis and PsA). OBJECTIVE: To summarize the current state of literature on the skin microbiome in PsD. METHODS: A systematic review was performed using searches in Ovid, Medline, Embase, Medline Epub Ahead of Print and In-Process & Other Non-Indexed Citations, and Cochrane Central Register of Controlled Trials (CENTRAL). Search was limited to humans and English language, with no limits for date or publication type. RESULTS: Of 4,032 citations identified, 9 studies met inclusion criteria (7 on psoriasis only and 2 studies compared the microbiome characteristics between psoriasis and PsA). Compared to healthy controls, lesions demonstrated a decreased alpha diversity, higher relative abundances of Firmicutes, and lower relative abundances of Actinobacteria. Less conclusive were genus-level results, which nonetheless demonstrated trends towards increased Streptococcus, Staphylococcus, and Corynebacterium and decreased Propionibacterium in lesions vs. control. LIMITATIONS: Study designs were heterogeneous, including sampling technique and exclusion criteria. CONCLUSIONS: Phyla- and selected genus-level characteristic of the psoriatic microbiome are presented; further research is warranted.
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spelling pubmed-73883782020-07-30 The skin microbiome in psoriatic disease: A systematic review and critical appraisal Yerushalmi, Meital Elalouf, Ofir Anderson, Melanie Chandran, Vinod J Transl Autoimmun Review article BACKGROUND: Psoriasis affects 1–3% of the Canadian population. Psoriatic arthritis (PsA), the most common comorbidity of psoriasis, affects up to 30% of psoriasis patients. The skin microbiome is hypothesized to play a role in the pathogenesis of psoriatic disease (PsD-psoriasis and PsA). OBJECTIVE: To summarize the current state of literature on the skin microbiome in PsD. METHODS: A systematic review was performed using searches in Ovid, Medline, Embase, Medline Epub Ahead of Print and In-Process & Other Non-Indexed Citations, and Cochrane Central Register of Controlled Trials (CENTRAL). Search was limited to humans and English language, with no limits for date or publication type. RESULTS: Of 4,032 citations identified, 9 studies met inclusion criteria (7 on psoriasis only and 2 studies compared the microbiome characteristics between psoriasis and PsA). Compared to healthy controls, lesions demonstrated a decreased alpha diversity, higher relative abundances of Firmicutes, and lower relative abundances of Actinobacteria. Less conclusive were genus-level results, which nonetheless demonstrated trends towards increased Streptococcus, Staphylococcus, and Corynebacterium and decreased Propionibacterium in lesions vs. control. LIMITATIONS: Study designs were heterogeneous, including sampling technique and exclusion criteria. CONCLUSIONS: Phyla- and selected genus-level characteristic of the psoriatic microbiome are presented; further research is warranted. Elsevier 2019-08-20 /pmc/articles/PMC7388378/ /pubmed/32743498 http://dx.doi.org/10.1016/j.jtauto.2019.100009 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review article
Yerushalmi, Meital
Elalouf, Ofir
Anderson, Melanie
Chandran, Vinod
The skin microbiome in psoriatic disease: A systematic review and critical appraisal
title The skin microbiome in psoriatic disease: A systematic review and critical appraisal
title_full The skin microbiome in psoriatic disease: A systematic review and critical appraisal
title_fullStr The skin microbiome in psoriatic disease: A systematic review and critical appraisal
title_full_unstemmed The skin microbiome in psoriatic disease: A systematic review and critical appraisal
title_short The skin microbiome in psoriatic disease: A systematic review and critical appraisal
title_sort skin microbiome in psoriatic disease: a systematic review and critical appraisal
topic Review article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388378/
https://www.ncbi.nlm.nih.gov/pubmed/32743498
http://dx.doi.org/10.1016/j.jtauto.2019.100009
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