Tissue damage from neutrophil-induced oxidative stress in COVID-19

The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell...

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Detalles Bibliográficos
Autores principales: Laforge, Mireille, Elbim, Carole, Frère, Corinne, Hémadi, Miryana, Massaad, Charbel, Nuss, Philippe, Benoliel, Jean-Jacques, Becker, Chrystel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388427/
https://www.ncbi.nlm.nih.gov/pubmed/32728221
http://dx.doi.org/10.1038/s41577-020-0407-1
Descripción
Sumario:The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. We suggest that free radical scavengers could be beneficial for the most vulnerable patients.

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