Tissue damage from neutrophil-induced oxidative stress in COVID-19

The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell...

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Autores principales: Laforge, Mireille, Elbim, Carole, Frère, Corinne, Hémadi, Miryana, Massaad, Charbel, Nuss, Philippe, Benoliel, Jean-Jacques, Becker, Chrystel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388427/
https://www.ncbi.nlm.nih.gov/pubmed/32728221
http://dx.doi.org/10.1038/s41577-020-0407-1
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author Laforge, Mireille
Elbim, Carole
Frère, Corinne
Hémadi, Miryana
Massaad, Charbel
Nuss, Philippe
Benoliel, Jean-Jacques
Becker, Chrystel
author_facet Laforge, Mireille
Elbim, Carole
Frère, Corinne
Hémadi, Miryana
Massaad, Charbel
Nuss, Philippe
Benoliel, Jean-Jacques
Becker, Chrystel
author_sort Laforge, Mireille
collection PubMed
description The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. We suggest that free radical scavengers could be beneficial for the most vulnerable patients.
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spelling pubmed-73884272020-07-29 Tissue damage from neutrophil-induced oxidative stress in COVID-19 Laforge, Mireille Elbim, Carole Frère, Corinne Hémadi, Miryana Massaad, Charbel Nuss, Philippe Benoliel, Jean-Jacques Becker, Chrystel Nat Rev Immunol Comment The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. We suggest that free radical scavengers could be beneficial for the most vulnerable patients. Nature Publishing Group UK 2020-07-29 2020 /pmc/articles/PMC7388427/ /pubmed/32728221 http://dx.doi.org/10.1038/s41577-020-0407-1 Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Laforge, Mireille
Elbim, Carole
Frère, Corinne
Hémadi, Miryana
Massaad, Charbel
Nuss, Philippe
Benoliel, Jean-Jacques
Becker, Chrystel
Tissue damage from neutrophil-induced oxidative stress in COVID-19
title Tissue damage from neutrophil-induced oxidative stress in COVID-19
title_full Tissue damage from neutrophil-induced oxidative stress in COVID-19
title_fullStr Tissue damage from neutrophil-induced oxidative stress in COVID-19
title_full_unstemmed Tissue damage from neutrophil-induced oxidative stress in COVID-19
title_short Tissue damage from neutrophil-induced oxidative stress in COVID-19
title_sort tissue damage from neutrophil-induced oxidative stress in covid-19
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388427/
https://www.ncbi.nlm.nih.gov/pubmed/32728221
http://dx.doi.org/10.1038/s41577-020-0407-1
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