The biological function of m6A demethylase ALKBH5 and its role in human disease

Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is dysregulated and acts as a biological and pharmacological role in human cancers or non-cancers. ALKBH5 plays a dual role in various cancers through regulating kinds of biological processes, such as proliferation, migration, invasi...

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Autores principales: Wang, Jinyan, Wang, Jinqiu, Gu, Quan, Ma, Yajun, Yang, Yan, Zhu, Jing, Zhang, Quan’an
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388453/
https://www.ncbi.nlm.nih.gov/pubmed/32742194
http://dx.doi.org/10.1186/s12935-020-01450-1
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author Wang, Jinyan
Wang, Jinqiu
Gu, Quan
Ma, Yajun
Yang, Yan
Zhu, Jing
Zhang, Quan’an
author_facet Wang, Jinyan
Wang, Jinqiu
Gu, Quan
Ma, Yajun
Yang, Yan
Zhu, Jing
Zhang, Quan’an
author_sort Wang, Jinyan
collection PubMed
description Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is dysregulated and acts as a biological and pharmacological role in human cancers or non-cancers. ALKBH5 plays a dual role in various cancers through regulating kinds of biological processes, such as proliferation, migration, invasion, metastasis and tumor growth. In addition, it takes a great part in human non-cancer, including reproductive system diseases. The underlying regulatory mechanisms of ALKBH5 that relys on m6A-dependent modification are implicated with long non-coding RNA, cancer stem cell, autophagy and hypoxia. ALKBH5 is also an independent prognostic indicator in various cancers. In this review, we summarized the current evidence on ALKBH5 in diverse human cancers or non-cancers and its potential as a prognostic target.
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spelling pubmed-73884532020-07-31 The biological function of m6A demethylase ALKBH5 and its role in human disease Wang, Jinyan Wang, Jinqiu Gu, Quan Ma, Yajun Yang, Yan Zhu, Jing Zhang, Quan’an Cancer Cell Int Review Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is dysregulated and acts as a biological and pharmacological role in human cancers or non-cancers. ALKBH5 plays a dual role in various cancers through regulating kinds of biological processes, such as proliferation, migration, invasion, metastasis and tumor growth. In addition, it takes a great part in human non-cancer, including reproductive system diseases. The underlying regulatory mechanisms of ALKBH5 that relys on m6A-dependent modification are implicated with long non-coding RNA, cancer stem cell, autophagy and hypoxia. ALKBH5 is also an independent prognostic indicator in various cancers. In this review, we summarized the current evidence on ALKBH5 in diverse human cancers or non-cancers and its potential as a prognostic target. BioMed Central 2020-07-28 /pmc/articles/PMC7388453/ /pubmed/32742194 http://dx.doi.org/10.1186/s12935-020-01450-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wang, Jinyan
Wang, Jinqiu
Gu, Quan
Ma, Yajun
Yang, Yan
Zhu, Jing
Zhang, Quan’an
The biological function of m6A demethylase ALKBH5 and its role in human disease
title The biological function of m6A demethylase ALKBH5 and its role in human disease
title_full The biological function of m6A demethylase ALKBH5 and its role in human disease
title_fullStr The biological function of m6A demethylase ALKBH5 and its role in human disease
title_full_unstemmed The biological function of m6A demethylase ALKBH5 and its role in human disease
title_short The biological function of m6A demethylase ALKBH5 and its role in human disease
title_sort biological function of m6a demethylase alkbh5 and its role in human disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388453/
https://www.ncbi.nlm.nih.gov/pubmed/32742194
http://dx.doi.org/10.1186/s12935-020-01450-1
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