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IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the most lethal forms of adult cancer with poor prognosis. Substantial evidence indicates that reactive oxygen species (ROS) are important modulators of aggressive cancer behavior. However, the mechanism by which ESCC cells integrate re...

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Detalles Bibliográficos
Autores principales: Liu, Zhenchuan, Gu, Shaorui, Lu, Tiancheng, Wu, Kaiqing, Li, Lei, Dong, Chenglai, Zhou, Yongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388476/
https://www.ncbi.nlm.nih.gov/pubmed/32727517
http://dx.doi.org/10.1186/s13046-020-01646-3

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