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Lapatinib-induced inhibition of ovarian function is counteracted by the STAT3 pathway both in vivo and in vitro

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The present study was designed to ascertain whether lapatinib, a tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR), affects ovarian reserve and fertility potential in a mouse model. Female C57BL/6 mice were treated with either vehicle or lapatinib (100 or 200 mg/kg/day orally) for...

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Detalles Bibliográficos
Autores principales:	Liao, Qiuyue, Feng, Xue, Li, Xi, Chen, Ge, Chen, Jing, Yang, Bin, Li, Kezhen, Ai, Jihui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388577/ https://www.ncbi.nlm.nih.gov/pubmed/32582968 http://dx.doi.org/10.3892/or.2020.7660

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