Temporospatial genomic profiling in glioblastoma identifies commonly altered core pathways underlying tumor progression

BACKGROUND: Tumor heterogeneity underlies resistance and disease progression in glioblastoma (GBM), and tumors most commonly recur adjacent to the surgical resection margins in contrast non-enhancing (NE) regions. To date, no targeted therapies have meaningfully altered overall patient survival in t...

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Detalles Bibliográficos
Autores principales: Blomquist, Mylan R, Ensign, Shannon Fortin, D’Angelo, Fulvio, Phillips, Joanna J, Ceccarelli, Michele, Peng, Sen, Halperin, Rebecca F, Caruso, Francesca P, Garofano, Luciano, Byron, Sara A, Liang, Winnie S, Craig, David W, Carpten, John D, Prados, Michael D, Trent, Jeffrey M, Berens, Michael E, Iavarone, Antonio, Dhruv, Harshil, Tran, Nhan L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388612/
https://www.ncbi.nlm.nih.gov/pubmed/32743548
http://dx.doi.org/10.1093/noajnl/vdaa078

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