Anti-HMGCR Specificity of HALIP: A Confirmatory Study

A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies...

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Autores principales: Baucells, Andrés, Martínez, Maria Angeles, Alvarado-Cardenas, Marcelo, Mariscal, Anaís, Martinez-Martinez, Laura, Juárez, Cándido, Selva-O'Callaghan, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388648/
https://www.ncbi.nlm.nih.gov/pubmed/32766318
http://dx.doi.org/10.1155/2020/6292631
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author Baucells, Andrés
Martínez, Maria Angeles
Alvarado-Cardenas, Marcelo
Mariscal, Anaís
Martinez-Martinez, Laura
Juárez, Cándido
Selva-O'Callaghan, Albert
author_facet Baucells, Andrés
Martínez, Maria Angeles
Alvarado-Cardenas, Marcelo
Mariscal, Anaís
Martinez-Martinez, Laura
Juárez, Cándido
Selva-O'Callaghan, Albert
author_sort Baucells, Andrés
collection PubMed
description A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients' sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. This study confirms that the HALIP is due to human anti-HMGCR antibodies.
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spelling pubmed-73886482020-08-05 Anti-HMGCR Specificity of HALIP: A Confirmatory Study Baucells, Andrés Martínez, Maria Angeles Alvarado-Cardenas, Marcelo Mariscal, Anaís Martinez-Martinez, Laura Juárez, Cándido Selva-O'Callaghan, Albert J Immunol Res Research Article A distinctive new indirect immunofluorescence pattern in liver tissue has been associated with anti-HMGCR autoantibodies. It is known as HALIP (HMGCR Associated Liver Immunofluorescence Pattern). In this study, we furthered the original studies to demonstrate the association of anti-HMGCR antibodies with the HALIP. Human anti-HMGCR antibodies from patients' sera were purified and incubated with rat triple tissue (kidney/stomach/liver). A characteristic HALIP was observed. Additionally, a colocalization assay of human anti-HMGCR antibodies with rabbit polyclonal anti-HMGCR antibodies showed colocalization of both immunofluorescence patterns. This study confirms that the HALIP is due to human anti-HMGCR antibodies. Hindawi 2020-07-16 /pmc/articles/PMC7388648/ /pubmed/32766318 http://dx.doi.org/10.1155/2020/6292631 Text en Copyright © 2020 Andrés Baucells et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Baucells, Andrés
Martínez, Maria Angeles
Alvarado-Cardenas, Marcelo
Mariscal, Anaís
Martinez-Martinez, Laura
Juárez, Cándido
Selva-O'Callaghan, Albert
Anti-HMGCR Specificity of HALIP: A Confirmatory Study
title Anti-HMGCR Specificity of HALIP: A Confirmatory Study
title_full Anti-HMGCR Specificity of HALIP: A Confirmatory Study
title_fullStr Anti-HMGCR Specificity of HALIP: A Confirmatory Study
title_full_unstemmed Anti-HMGCR Specificity of HALIP: A Confirmatory Study
title_short Anti-HMGCR Specificity of HALIP: A Confirmatory Study
title_sort anti-hmgcr specificity of halip: a confirmatory study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388648/
https://www.ncbi.nlm.nih.gov/pubmed/32766318
http://dx.doi.org/10.1155/2020/6292631
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