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Review on the Recent Advances on Typhoid Vaccine Development and Challenges Ahead

Control of Salmonella enterica serovar typhi (S. typhi), the agent of typhoid fever, continues to be a challenge in many low- and middle-income countries. The major transmission route of S. typhi is fecal-oral, through contaminated food and water; thus, the ultimate measures for typhoid fever preven...

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Autores principales: Syed, Khalid Ali, Saluja, Tarun, Cho, Heeyoun, Hsiao, Amber, Shaikh, Hanif, Wartel, T Anh, Mogasale, Vittal, Lynch, Julia, Kim, Jerome H, Excler, Jean-Louis, Sahastrabuddhe, Sushant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388714/
https://www.ncbi.nlm.nih.gov/pubmed/32725225
http://dx.doi.org/10.1093/cid/ciaa504
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author Syed, Khalid Ali
Saluja, Tarun
Cho, Heeyoun
Hsiao, Amber
Shaikh, Hanif
Wartel, T Anh
Mogasale, Vittal
Lynch, Julia
Kim, Jerome H
Excler, Jean-Louis
Sahastrabuddhe, Sushant
author_facet Syed, Khalid Ali
Saluja, Tarun
Cho, Heeyoun
Hsiao, Amber
Shaikh, Hanif
Wartel, T Anh
Mogasale, Vittal
Lynch, Julia
Kim, Jerome H
Excler, Jean-Louis
Sahastrabuddhe, Sushant
author_sort Syed, Khalid Ali
collection PubMed
description Control of Salmonella enterica serovar typhi (S. typhi), the agent of typhoid fever, continues to be a challenge in many low- and middle-income countries. The major transmission route of S. typhi is fecal-oral, through contaminated food and water; thus, the ultimate measures for typhoid fever prevention and control include the provision of safe water, improved sanitation, and hygiene. Considering the increasing evidence of the global burden of typhoid, particularly among young children, and the long-term horizon for sustained, effective water and sanitation improvements in low-income settings, a growing consensus is to emphasize preventive vaccination. This review provides an overview of the licensed typhoid vaccines and vaccine candidates under development, and the challenges ahead for introduction.
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spelling pubmed-73887142020-08-04 Review on the Recent Advances on Typhoid Vaccine Development and Challenges Ahead Syed, Khalid Ali Saluja, Tarun Cho, Heeyoun Hsiao, Amber Shaikh, Hanif Wartel, T Anh Mogasale, Vittal Lynch, Julia Kim, Jerome H Excler, Jean-Louis Sahastrabuddhe, Sushant Clin Infect Dis Supplement Articles Control of Salmonella enterica serovar typhi (S. typhi), the agent of typhoid fever, continues to be a challenge in many low- and middle-income countries. The major transmission route of S. typhi is fecal-oral, through contaminated food and water; thus, the ultimate measures for typhoid fever prevention and control include the provision of safe water, improved sanitation, and hygiene. Considering the increasing evidence of the global burden of typhoid, particularly among young children, and the long-term horizon for sustained, effective water and sanitation improvements in low-income settings, a growing consensus is to emphasize preventive vaccination. This review provides an overview of the licensed typhoid vaccines and vaccine candidates under development, and the challenges ahead for introduction. Oxford University Press 2020-08-15 2020-07-29 /pmc/articles/PMC7388714/ /pubmed/32725225 http://dx.doi.org/10.1093/cid/ciaa504 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Supplement Articles
Syed, Khalid Ali
Saluja, Tarun
Cho, Heeyoun
Hsiao, Amber
Shaikh, Hanif
Wartel, T Anh
Mogasale, Vittal
Lynch, Julia
Kim, Jerome H
Excler, Jean-Louis
Sahastrabuddhe, Sushant
Review on the Recent Advances on Typhoid Vaccine Development and Challenges Ahead
title Review on the Recent Advances on Typhoid Vaccine Development and Challenges Ahead
title_full Review on the Recent Advances on Typhoid Vaccine Development and Challenges Ahead
title_fullStr Review on the Recent Advances on Typhoid Vaccine Development and Challenges Ahead
title_full_unstemmed Review on the Recent Advances on Typhoid Vaccine Development and Challenges Ahead
title_short Review on the Recent Advances on Typhoid Vaccine Development and Challenges Ahead
title_sort review on the recent advances on typhoid vaccine development and challenges ahead
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388714/
https://www.ncbi.nlm.nih.gov/pubmed/32725225
http://dx.doi.org/10.1093/cid/ciaa504
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