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The Mechanism of Ferroptosis and Applications in Tumor Treatment

Iron-dependent ferroptosis is a new form of cell death in recent years, which is driven by lipid peroxidation. The lethal lipid accumulation caused by glutathione depletion or inactivation of glutathione peroxidase 4 (GPX4) is characteristic of the ferroptosis process. In recent years, with the in-d...

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Autores principales: Lin, Xinyue, Ping, Jieyi, Wen, Yi, Wu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388725/
https://www.ncbi.nlm.nih.gov/pubmed/32774303
http://dx.doi.org/10.3389/fphar.2020.01061
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author Lin, Xinyue
Ping, Jieyi
Wen, Yi
Wu, Yan
author_facet Lin, Xinyue
Ping, Jieyi
Wen, Yi
Wu, Yan
author_sort Lin, Xinyue
collection PubMed
description Iron-dependent ferroptosis is a new form of cell death in recent years, which is driven by lipid peroxidation. The lethal lipid accumulation caused by glutathione depletion or inactivation of glutathione peroxidase 4 (GPX4) is characteristic of the ferroptosis process. In recent years, with the in-depth study of ferroptosis, various types of diseases have been reported to be related to ferroptosis. In other words, ferroptosis, which has attracted widespread attention in the fields of biochemistry, oncology, and especially materials science, can undoubtedly provide a new way for patients. This review introduces the relevant mechanisms of ferroptosis, the relationship between ferroptosis and various cancers, as well as the application of ferroptosis in tumor treatment. We also sorted out the genes and drugs that regulate ferroptosis. Moreover, small molecule compound-induced ferroptosis has a strong inhibitory effect on tumor growth in a drug-resistant environment, which can enhance the sensitivity of chemotherapeutic drugs, suggesting that ferroptosis is very important in the treatment of tumor drug resistance, but the details are still unclear. How to use ferroptosis to fight cancer, and how to prevent drug-resistant tumor cells have become the focus and direction of research. At the end of the article, some existing problems related to ferroptosis are summarized for future research.
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spelling pubmed-73887252020-08-07 The Mechanism of Ferroptosis and Applications in Tumor Treatment Lin, Xinyue Ping, Jieyi Wen, Yi Wu, Yan Front Pharmacol Pharmacology Iron-dependent ferroptosis is a new form of cell death in recent years, which is driven by lipid peroxidation. The lethal lipid accumulation caused by glutathione depletion or inactivation of glutathione peroxidase 4 (GPX4) is characteristic of the ferroptosis process. In recent years, with the in-depth study of ferroptosis, various types of diseases have been reported to be related to ferroptosis. In other words, ferroptosis, which has attracted widespread attention in the fields of biochemistry, oncology, and especially materials science, can undoubtedly provide a new way for patients. This review introduces the relevant mechanisms of ferroptosis, the relationship between ferroptosis and various cancers, as well as the application of ferroptosis in tumor treatment. We also sorted out the genes and drugs that regulate ferroptosis. Moreover, small molecule compound-induced ferroptosis has a strong inhibitory effect on tumor growth in a drug-resistant environment, which can enhance the sensitivity of chemotherapeutic drugs, suggesting that ferroptosis is very important in the treatment of tumor drug resistance, but the details are still unclear. How to use ferroptosis to fight cancer, and how to prevent drug-resistant tumor cells have become the focus and direction of research. At the end of the article, some existing problems related to ferroptosis are summarized for future research. Frontiers Media S.A. 2020-07-22 /pmc/articles/PMC7388725/ /pubmed/32774303 http://dx.doi.org/10.3389/fphar.2020.01061 Text en Copyright © 2020 Lin, Ping, Wen and Wu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Lin, Xinyue
Ping, Jieyi
Wen, Yi
Wu, Yan
The Mechanism of Ferroptosis and Applications in Tumor Treatment
title The Mechanism of Ferroptosis and Applications in Tumor Treatment
title_full The Mechanism of Ferroptosis and Applications in Tumor Treatment
title_fullStr The Mechanism of Ferroptosis and Applications in Tumor Treatment
title_full_unstemmed The Mechanism of Ferroptosis and Applications in Tumor Treatment
title_short The Mechanism of Ferroptosis and Applications in Tumor Treatment
title_sort mechanism of ferroptosis and applications in tumor treatment
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388725/
https://www.ncbi.nlm.nih.gov/pubmed/32774303
http://dx.doi.org/10.3389/fphar.2020.01061
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