Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report

BACKGROUND: Routine clinical and pathological examinations usually cannot fully conclusively determine the relationship between different lesions of lung cancer. Detailed genetic analysis of tumor samples may supply important additional information and identify second primary lung cancers. CASE PRES...

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Detalles Bibliográficos
Autores principales: Yang, Yong, Xie, Xiaofeng, Jiang, Gening, Liu, Hongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389679/
https://www.ncbi.nlm.nih.gov/pubmed/32727606
http://dx.doi.org/10.1186/s13019-020-01178-z
Descripción
Sumario:BACKGROUND: Routine clinical and pathological examinations usually cannot fully conclusively determine the relationship between different lesions of lung cancer. Detailed genetic analysis of tumor samples may supply important additional information and identify second primary lung cancers. CASE PRESENTATION: In the present study, we report a case of synchronous multiple primary lung cancer (MPLC) composed of two distinct pathological subtypes with epidermal growth factor receptor (EGFR) gene mutations L858R of the acinar adenocarcinoma subtype and EML4–ALK rearrangement of the squamous cell carcinoma. CONCLUSION: The present report highlights the clinical importance of molecular cancer biomarkers detection to guide management decisions in MPLC cases.

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