Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report

BACKGROUND: Routine clinical and pathological examinations usually cannot fully conclusively determine the relationship between different lesions of lung cancer. Detailed genetic analysis of tumor samples may supply important additional information and identify second primary lung cancers. CASE PRES...

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Autores principales: Yang, Yong, Xie, Xiaofeng, Jiang, Gening, Liu, Hongcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389679/
https://www.ncbi.nlm.nih.gov/pubmed/32727606
http://dx.doi.org/10.1186/s13019-020-01178-z
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author Yang, Yong
Xie, Xiaofeng
Jiang, Gening
Liu, Hongcheng
author_facet Yang, Yong
Xie, Xiaofeng
Jiang, Gening
Liu, Hongcheng
author_sort Yang, Yong
collection PubMed
description BACKGROUND: Routine clinical and pathological examinations usually cannot fully conclusively determine the relationship between different lesions of lung cancer. Detailed genetic analysis of tumor samples may supply important additional information and identify second primary lung cancers. CASE PRESENTATION: In the present study, we report a case of synchronous multiple primary lung cancer (MPLC) composed of two distinct pathological subtypes with epidermal growth factor receptor (EGFR) gene mutations L858R of the acinar adenocarcinoma subtype and EML4–ALK rearrangement of the squamous cell carcinoma. CONCLUSION: The present report highlights the clinical importance of molecular cancer biomarkers detection to guide management decisions in MPLC cases.
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spelling pubmed-73896792020-07-31 Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report Yang, Yong Xie, Xiaofeng Jiang, Gening Liu, Hongcheng J Cardiothorac Surg Case Report BACKGROUND: Routine clinical and pathological examinations usually cannot fully conclusively determine the relationship between different lesions of lung cancer. Detailed genetic analysis of tumor samples may supply important additional information and identify second primary lung cancers. CASE PRESENTATION: In the present study, we report a case of synchronous multiple primary lung cancer (MPLC) composed of two distinct pathological subtypes with epidermal growth factor receptor (EGFR) gene mutations L858R of the acinar adenocarcinoma subtype and EML4–ALK rearrangement of the squamous cell carcinoma. CONCLUSION: The present report highlights the clinical importance of molecular cancer biomarkers detection to guide management decisions in MPLC cases. BioMed Central 2020-07-29 /pmc/articles/PMC7389679/ /pubmed/32727606 http://dx.doi.org/10.1186/s13019-020-01178-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Yang, Yong
Xie, Xiaofeng
Jiang, Gening
Liu, Hongcheng
Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report
title Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report
title_full Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report
title_fullStr Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report
title_full_unstemmed Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report
title_short Different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report
title_sort different driver gene mutations in patients with synchronous multiple primary lung cancers: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389679/
https://www.ncbi.nlm.nih.gov/pubmed/32727606
http://dx.doi.org/10.1186/s13019-020-01178-z
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AT jianggening differentdrivergenemutationsinpatientswithsynchronousmultipleprimarylungcancersacasereport
AT liuhongcheng differentdrivergenemutationsinpatientswithsynchronousmultipleprimarylungcancersacasereport

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