LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes

BACKGROUND: Pancreatic cancer is one of the most lethal malignancies and has an extremely poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major challenge. The long noncoding RNA PVT1 was reported to be involved in carcinogenesis and chemoresistance; however, the...

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Detalles Bibliográficos
Autores principales: Zhou, Cefan, Yi, Changhua, Yi, Yongxiang, Qin, Wenying, Yan, Yanan, Dong, Xueying, Zhang, Xuewen, Huang, Yuan, Zhang, Rui, Wei, Jie, Ali, Declan William, Michalak, Marek, Chen, Xing-Zhen, Tang, Jingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389684/
https://www.ncbi.nlm.nih.gov/pubmed/32727463
http://dx.doi.org/10.1186/s12943-020-01237-y

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