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PTC located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis
BACKGROUND: Lateral lymph node metastasis (LLNM) is very common in papillary thyroid carcinoma (PTC). The influence of tumour location on LLNM remains controversial. The purpose of this study was to reveal the association between PTC tumours located in the upper pole and LLNM. METHODS: We reviewed a...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389816/ https://www.ncbi.nlm.nih.gov/pubmed/32723382 http://dx.doi.org/10.1186/s12957-020-01965-x |
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author | Dou, Yi Hu, Daixing Chen, Yingji Xiong, Wei Xiao, Qi Su, Xinliang |
author_facet | Dou, Yi Hu, Daixing Chen, Yingji Xiong, Wei Xiao, Qi Su, Xinliang |
author_sort | Dou, Yi |
collection | PubMed |
description | BACKGROUND: Lateral lymph node metastasis (LLNM) is very common in papillary thyroid carcinoma (PTC). The influence of tumour location on LLNM remains controversial. The purpose of this study was to reveal the association between PTC tumours located in the upper pole and LLNM. METHODS: We reviewed a total of 1773 PTC patients who underwent total thyroidectomy with central and lateral lymph node dissection between 2013 and 2018. Patients were divided into two groups according to tumour location. Univariate and multivariate analyses were performed to identify risk factors associated with LLNM and “skip metastasis”. RESULTS: In the upper pole group, LLNM and skip metastasis were significantly likely to occur. Multivariate analysis showed that tumours located in the upper pole, male sex, extrathyroidal extension (ETE), central lymph node metastasis (CLNM) and tumour size were independent risk factors for LLNM, with odds ratios ([ORs], 95% confidence intervals [CIs]) of 2.136 (1.707–2.672), 1.486 (1.184–1.867), 1.332 (1.031–1.72), 4.172 (3.279–5.308) and 2.496 (1.844–3.380), respectively. Skip metastasis was significantly associated with the primary tumour location in the upper pole and age > 55 years, with ORs of 4.295 (2.885–6.395) and 2.354 (1.522–3.640), respectively. CONCLUSIONS: In our opinion, papillary thyroid tumours located in the upper pole may have an exclusive drainage pathway to the lateral lymph nodes. When the tumour is located in the upper pole, lateral neck dissection should be evaluated meticulously. |
format | Online Article Text |
id | pubmed-7389816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73898162020-07-31 PTC located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis Dou, Yi Hu, Daixing Chen, Yingji Xiong, Wei Xiao, Qi Su, Xinliang World J Surg Oncol Research BACKGROUND: Lateral lymph node metastasis (LLNM) is very common in papillary thyroid carcinoma (PTC). The influence of tumour location on LLNM remains controversial. The purpose of this study was to reveal the association between PTC tumours located in the upper pole and LLNM. METHODS: We reviewed a total of 1773 PTC patients who underwent total thyroidectomy with central and lateral lymph node dissection between 2013 and 2018. Patients were divided into two groups according to tumour location. Univariate and multivariate analyses were performed to identify risk factors associated with LLNM and “skip metastasis”. RESULTS: In the upper pole group, LLNM and skip metastasis were significantly likely to occur. Multivariate analysis showed that tumours located in the upper pole, male sex, extrathyroidal extension (ETE), central lymph node metastasis (CLNM) and tumour size were independent risk factors for LLNM, with odds ratios ([ORs], 95% confidence intervals [CIs]) of 2.136 (1.707–2.672), 1.486 (1.184–1.867), 1.332 (1.031–1.72), 4.172 (3.279–5.308) and 2.496 (1.844–3.380), respectively. Skip metastasis was significantly associated with the primary tumour location in the upper pole and age > 55 years, with ORs of 4.295 (2.885–6.395) and 2.354 (1.522–3.640), respectively. CONCLUSIONS: In our opinion, papillary thyroid tumours located in the upper pole may have an exclusive drainage pathway to the lateral lymph nodes. When the tumour is located in the upper pole, lateral neck dissection should be evaluated meticulously. BioMed Central 2020-07-28 /pmc/articles/PMC7389816/ /pubmed/32723382 http://dx.doi.org/10.1186/s12957-020-01965-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Dou, Yi Hu, Daixing Chen, Yingji Xiong, Wei Xiao, Qi Su, Xinliang PTC located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis |
title | PTC located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis |
title_full | PTC located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis |
title_fullStr | PTC located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis |
title_full_unstemmed | PTC located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis |
title_short | PTC located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis |
title_sort | ptc located in the upper pole is more prone to lateral lymph node metastasis and skip metastasis |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389816/ https://www.ncbi.nlm.nih.gov/pubmed/32723382 http://dx.doi.org/10.1186/s12957-020-01965-x |
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