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Protein-Protein interactions uncover candidate ‘core genes’ within omnigenic disease networks
Genome wide association studies (GWAS) of human diseases have generally identified many loci associated with risk with relatively small effect sizes. The omnigenic model attempts to explain this observation by suggesting that diseases can be thought of as networks, where genes with direct involvemen...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390454/ https://www.ncbi.nlm.nih.gov/pubmed/32678846 http://dx.doi.org/10.1371/journal.pgen.1008903 |