Cargando…

Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities

To explore the underlying pathogenic mechanism of Parkinson’s disease (PD) with concomitant postural abnormalities (PDPA) through the relationship between its gait and brain function characteristics. PD patients from the neurology outpatient clinic at Ruijin Hospital were recruited and grouped accor...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Meng-sha, Zhou, Li-che, Tan, Yu-yan, Jiang, Hong, Chen, Zhi-chun, Zhu, Lin, Luo, Ning-di, Wu, Quan-zhou, Kang, Wen-yan, Liu, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390521/
https://www.ncbi.nlm.nih.gov/pubmed/32765946
http://dx.doi.org/10.14336/AD.2019.0929
_version_ 1783564466397380608
author Yao, Meng-sha
Zhou, Li-che
Tan, Yu-yan
Jiang, Hong
Chen, Zhi-chun
Zhu, Lin
Luo, Ning-di
Wu, Quan-zhou
Kang, Wen-yan
Liu, Jun
author_facet Yao, Meng-sha
Zhou, Li-che
Tan, Yu-yan
Jiang, Hong
Chen, Zhi-chun
Zhu, Lin
Luo, Ning-di
Wu, Quan-zhou
Kang, Wen-yan
Liu, Jun
author_sort Yao, Meng-sha
collection PubMed
description To explore the underlying pathogenic mechanism of Parkinson’s disease (PD) with concomitant postural abnormalities (PDPA) through the relationship between its gait and brain function characteristics. PD patients from the neurology outpatient clinic at Ruijin Hospital were recruited and grouped according to whether postural abnormalities (including camptocormia and Pisa syndrome) were present. PD-related scale assessments, three-dimensional gait tests and brain resting-state functional magnetic imaging were performed and analyzed. The gait characteristics independently associated with PDPA were decreased pelvic obliquity angle and progressive downward movement of the center of mass during walking. PDPA features included decreased functional connectivity between the left insula and bilateral supplementary motor area, which was significantly correlated with reduced Berg Balance Scale scores. Functional connectivity between the right insula and bilateral middle frontal gyrus was decreased and significantly correlated with a decreased pelvic obliquity angle and poor performance on the Timed Up and Go test. Moreover, through diffusion tensor imaging analysis, the average fractional anisotropy value of the fibers connecting the left insula and left supplementary motor area was shown to be decreased in PDPA. There is decreased functional connectivity among the insula, supplementary motor area and middle frontal gyrus with structural abnormalities between the left insula and the left supplementary motor area; these changes in brain connectivity are probably among the causes of gait dysfunction in PDPA and provide some clues regarding the pathogenic mechanisms of PDPA.
format Online
Article
Text
id pubmed-7390521
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher JKL International LLC
record_format MEDLINE/PubMed
spelling pubmed-73905212020-08-05 Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities Yao, Meng-sha Zhou, Li-che Tan, Yu-yan Jiang, Hong Chen, Zhi-chun Zhu, Lin Luo, Ning-di Wu, Quan-zhou Kang, Wen-yan Liu, Jun Aging Dis Orginal Article To explore the underlying pathogenic mechanism of Parkinson’s disease (PD) with concomitant postural abnormalities (PDPA) through the relationship between its gait and brain function characteristics. PD patients from the neurology outpatient clinic at Ruijin Hospital were recruited and grouped according to whether postural abnormalities (including camptocormia and Pisa syndrome) were present. PD-related scale assessments, three-dimensional gait tests and brain resting-state functional magnetic imaging were performed and analyzed. The gait characteristics independently associated with PDPA were decreased pelvic obliquity angle and progressive downward movement of the center of mass during walking. PDPA features included decreased functional connectivity between the left insula and bilateral supplementary motor area, which was significantly correlated with reduced Berg Balance Scale scores. Functional connectivity between the right insula and bilateral middle frontal gyrus was decreased and significantly correlated with a decreased pelvic obliquity angle and poor performance on the Timed Up and Go test. Moreover, through diffusion tensor imaging analysis, the average fractional anisotropy value of the fibers connecting the left insula and left supplementary motor area was shown to be decreased in PDPA. There is decreased functional connectivity among the insula, supplementary motor area and middle frontal gyrus with structural abnormalities between the left insula and the left supplementary motor area; these changes in brain connectivity are probably among the causes of gait dysfunction in PDPA and provide some clues regarding the pathogenic mechanisms of PDPA. JKL International LLC 2020-07-23 /pmc/articles/PMC7390521/ /pubmed/32765946 http://dx.doi.org/10.14336/AD.2019.0929 Text en Copyright: © 2020 Yao et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Orginal Article
Yao, Meng-sha
Zhou, Li-che
Tan, Yu-yan
Jiang, Hong
Chen, Zhi-chun
Zhu, Lin
Luo, Ning-di
Wu, Quan-zhou
Kang, Wen-yan
Liu, Jun
Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities
title Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities
title_full Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities
title_fullStr Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities
title_full_unstemmed Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities
title_short Gait Characteristics and Brain Activity in Parkinson’s Disease with Concomitant Postural Abnormalities
title_sort gait characteristics and brain activity in parkinson’s disease with concomitant postural abnormalities
topic Orginal Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390521/
https://www.ncbi.nlm.nih.gov/pubmed/32765946
http://dx.doi.org/10.14336/AD.2019.0929
work_keys_str_mv AT yaomengsha gaitcharacteristicsandbrainactivityinparkinsonsdiseasewithconcomitantposturalabnormalities
AT zhouliche gaitcharacteristicsandbrainactivityinparkinsonsdiseasewithconcomitantposturalabnormalities
AT tanyuyan gaitcharacteristicsandbrainactivityinparkinsonsdiseasewithconcomitantposturalabnormalities
AT jianghong gaitcharacteristicsandbrainactivityinparkinsonsdiseasewithconcomitantposturalabnormalities
AT chenzhichun gaitcharacteristicsandbrainactivityinparkinsonsdiseasewithconcomitantposturalabnormalities
AT zhulin gaitcharacteristicsandbrainactivityinparkinsonsdiseasewithconcomitantposturalabnormalities
AT luoningdi gaitcharacteristicsandbrainactivityinparkinsonsdiseasewithconcomitantposturalabnormalities
AT wuquanzhou gaitcharacteristicsandbrainactivityinparkinsonsdiseasewithconcomitantposturalabnormalities
AT kangwenyan gaitcharacteristicsandbrainactivityinparkinsonsdiseasewithconcomitantposturalabnormalities
AT liujun gaitcharacteristicsandbrainactivityinparkinsonsdiseasewithconcomitantposturalabnormalities