Brief Review of Chloroquine and Hydroxychloroquine Toxicity and Management

As of April 21, 2020, more than 2.5 million cases of coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, have been reported in 210 countries and territories, with the death toll at 171,810. Both chloroquine and hydroxychloroquine have gained considerable media attention as possible...

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Detalles Bibliográficos
Autores principales: Lebin, Jacob A., LeSaint, Kathy T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Department of Emergency Medicine, University of California, Irvine School of Medicine 2020
Materias:
Endemic Infections
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390560/
https://www.ncbi.nlm.nih.gov/pubmed/32726238
http://dx.doi.org/10.5811/westjem.2020.5.47810
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author Lebin, Jacob A.
LeSaint, Kathy T.
author_facet Lebin, Jacob A.
LeSaint, Kathy T.
author_sort Lebin, Jacob A.
collection PubMed
description As of April 21, 2020, more than 2.5 million cases of coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, have been reported in 210 countries and territories, with the death toll at 171,810. Both chloroquine and hydroxychloroquine have gained considerable media attention as possible therapies, resulting in a significant surge in demand. In overdose, both medications can cause severe, potentially life-threatening effects. Here, we present a brief overview of the pharmacology of chloroquine and hydroxychloroquine, manifestations of toxicity, and treatment considerations.
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spelling pubmed-73905602020-07-31 Brief Review of Chloroquine and Hydroxychloroquine Toxicity and Management Lebin, Jacob A. LeSaint, Kathy T. West J Emerg Med Endemic Infections As of April 21, 2020, more than 2.5 million cases of coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, have been reported in 210 countries and territories, with the death toll at 171,810. Both chloroquine and hydroxychloroquine have gained considerable media attention as possible therapies, resulting in a significant surge in demand. In overdose, both medications can cause severe, potentially life-threatening effects. Here, we present a brief overview of the pharmacology of chloroquine and hydroxychloroquine, manifestations of toxicity, and treatment considerations. Department of Emergency Medicine, University of California, Irvine School of Medicine 2020-07 2020-06-03 /pmc/articles/PMC7390560/ /pubmed/32726238 http://dx.doi.org/10.5811/westjem.2020.5.47810 Text en Copyright: © 2020 Lebin et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) License. See: http://creativecommons.org/licenses/by/4.0/
spellingShingle Endemic Infections
Lebin, Jacob A.
LeSaint, Kathy T.
Brief Review of Chloroquine and Hydroxychloroquine Toxicity and Management
title Brief Review of Chloroquine and Hydroxychloroquine Toxicity and Management
title_full Brief Review of Chloroquine and Hydroxychloroquine Toxicity and Management
title_fullStr Brief Review of Chloroquine and Hydroxychloroquine Toxicity and Management
title_full_unstemmed Brief Review of Chloroquine and Hydroxychloroquine Toxicity and Management
title_short Brief Review of Chloroquine and Hydroxychloroquine Toxicity and Management
title_sort brief review of chloroquine and hydroxychloroquine toxicity and management
topic Endemic Infections
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390560/
https://www.ncbi.nlm.nih.gov/pubmed/32726238
http://dx.doi.org/10.5811/westjem.2020.5.47810
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