Cargando…

Endothelial protective factors BMP9 and BMP10 inhibit CCL2 release by human vascular endothelial cells

Bone morphogenetic protein 9 (BMP9) and BMP10 are circulating ligands that mediate endothelial cell (EC) protection via complexes of the type I receptor ALK1 and the type II receptors activin type-IIA receptor (ACTR-IIA) and bone morphogenetic type II receptor (BMPR-II). We previously demonstrated t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Upton, Paul D., Park, John E. S., De Souza, Patricia M., Davies, Rachel J., Griffiths, Mark J. D., Wort, Stephen J., Morrell, Nicholas W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390625/ https://www.ncbi.nlm.nih.gov/pubmed/32576665 http://dx.doi.org/10.1242/jcs.239715

Ejemplares similares

BMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production
por: Park, John E. S., et al.
Publicado: (2012)

Correction: BMP-9 Induced Endothelial Cell Tubule Formation and Inhibition of Migration Involves Smad1 Driven Endothelin-1 Production
por: Park, John E. S., et al.
Publicado: (2013)

Reduced circulating BMP9 and pBMP10 in hospitalized COVID‐19 patients
por: Dunmore, Benjamin J., et al.
Publicado: (2023)

Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis
por: Owen, Nicola E., et al.
Publicado: (2020)

High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells
por: Andersson-Rusch, Clara, et al.
Publicado: (2023)

A rare homozygous missense GDF2 (BMP9) mutation causing PAH in siblings: Does BMP10 status contribute?
por: Upton, Paul, et al.
Publicado: (2022)

Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension
por: Long, Lu, et al.
Publicado: (2015)

Bone morphogenetic protein 9 (BMP9) and BMP10 enhance tumor necrosis factor-α-induced monocyte recruitment to the vascular endothelium mainly via activin receptor-like kinase 2
por: Mitrofan, Claudia-Gabriela, et al.
Publicado: (2017)

Regulation of Bone Morphogenetic Protein 9 (BMP9) by Redox-dependent Proteolysis
por: Wei, Zhenquan, et al.
Publicado: (2014)

The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations
por: Dunmore, Benjamin J., et al.
Publicado: (2013)

Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms
por: Salmon, Richard M., et al.
Publicado: (2020)

The Role of BMP Signaling in Endothelial Heterogeneity
por: Han, Orjin, et al.
Publicado: (2021)

Homozygous GDF2 nonsense mutations result in a loss of circulating BMP9 and BMP10 and are associated with either PAH or an “HHT‐like” syndrome in children
por: Hodgson, Joshua, et al.
Publicado: (2021)

Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia
por: Tillet, Emmanuelle, et al.
Publicado: (2015)

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression
por: Vion, Anne-Clémence, et al.
Publicado: (2018)

Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells
por: Tachida, Yuki, et al.
Publicado: (2017)

RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells
por: Tang, Shi, et al.
Publicado: (2022)

Role of soluble endoglin in BMP9 signaling
por: Lawera, Aleksandra, et al.
Publicado: (2019)

MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling
por: Watterston, Charlene, et al.
Publicado: (2019)

Long Bone Structure and Strength Depend on BMP2 from Osteoblasts and Osteocytes, but Not Vascular Endothelial Cells
por: McBride, Sarah H., et al.
Publicado: (2014)

BMP10 functions independently from BMP9 for the development of a proper arteriovenous network
por: Choi, Hyunwoo, et al.
Publicado: (2022)

The promise of recombinant BMP ligands and other approaches targeting BMPR-II in the treatment of pulmonary arterial hypertension
por: Ormiston, Mark L., et al.
Publicado: (2015)

BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses
por: Young, Kira, et al.
Publicado: (2015)

BMP9 in Acute Respiratory Distress Syndrome: Decades of BMP Studies in Vascular Biology Paying Off?
por: West, James
Publicado: (2021)

BMP-2 Promotes Oral Squamous Carcinoma Cell Invasion by Inducing CCL5 Release
por: Kim, Mi-joo, et al.
Publicado: (2014)

Implications of BMP9/10 for patients with liver cirrhosis
por: Ji, Dong, et al.
Publicado: (2020)

BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells
por: Tao, Bo, et al.
Publicado: (2021)

Multiple pathways coordinating reprogramming of endothelial cells into osteoblasts by BMP4
por: Yu, Guoyu, et al.
Publicado: (2021)

A mouse model of hereditary hemorrhagic telangiectasia generated by transmammary-delivered immunoblocking of BMP9 and BMP10
por: Ruiz, Santiago, et al.
Publicado: (2016)

Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10
por: Bouvard, Claire, et al.
Publicado: (2021)

Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis
por: Bandyopadhyay, Amitabha, et al.
Publicado: (2006)

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling
por: Benn, Andreas, et al.
Publicado: (2016)

Exacerbated inflammatory signaling underlies aberrant response to BMP9 in pulmonary arterial hypertension lung endothelial cells
por: Szulcek, Robert, et al.
Publicado: (2020)

Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities
por: Berasi, Stephen P, et al.
Publicado: (2011)

Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10
por: Guo, Jingxu, et al.
Publicado: (2022)

BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks
por: Beets, Karen, et al.
Publicado: (2016)

Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells
por: Wu, Xiuju, et al.
Publicado: (2019)

It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology
por: Hiepen, Christian, et al.
Publicado: (2020)

The versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function
por: Kulikauskas, Molly R., et al.
Publicado: (2022)

BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF
por: Pulkkinen, H. H., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_cudgkdi4nuktqrkrf7c85bs3es