Cargando…

The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [(11)C]PBR28 binding and exploration of its link to post-operative delirium

Major surgery is associated with a systemic inflammatory cascade that is thought, in some cases, to contribute to transient and/or sustained cognitive decline, possibly through neuroinflammatory mechanisms. However, the relationship between surgery, peripheral and central nervous system inflammation...

Descripción completa

Detalles Bibliográficos
Autores principales: Katsumi, Yuta, Racine, Annie M., Torrado-Carvajal, Angel, Loggia, Marco L., Hooker, Jacob M., Greve, Douglas N., Hightower, Baileigh G., Catana, Ciprian, Cavallari, Michele, Arnold, Steven E., Fong, Tamara G., Vasunilashorn, Sarinnapha M., Marcantonio, Edward R., Schmitt, Eva M., Xu, Guoquan, Libermann, Towia A., Barrett, Lisa Feldman, Inouye, Sharon K., Dickerson, Bradford C., Touroutoglou, Alexandra, Collins, Jessica A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390821/
https://www.ncbi.nlm.nih.gov/pubmed/32712451
http://dx.doi.org/10.1016/j.nicl.2020.102346
_version_ 1783564521061744640
author Katsumi, Yuta
Racine, Annie M.
Torrado-Carvajal, Angel
Loggia, Marco L.
Hooker, Jacob M.
Greve, Douglas N.
Hightower, Baileigh G.
Catana, Ciprian
Cavallari, Michele
Arnold, Steven E.
Fong, Tamara G.
Vasunilashorn, Sarinnapha M.
Marcantonio, Edward R.
Schmitt, Eva M.
Xu, Guoquan
Libermann, Towia A.
Barrett, Lisa Feldman
Inouye, Sharon K.
Dickerson, Bradford C.
Touroutoglou, Alexandra
Collins, Jessica A.
author_facet Katsumi, Yuta
Racine, Annie M.
Torrado-Carvajal, Angel
Loggia, Marco L.
Hooker, Jacob M.
Greve, Douglas N.
Hightower, Baileigh G.
Catana, Ciprian
Cavallari, Michele
Arnold, Steven E.
Fong, Tamara G.
Vasunilashorn, Sarinnapha M.
Marcantonio, Edward R.
Schmitt, Eva M.
Xu, Guoquan
Libermann, Towia A.
Barrett, Lisa Feldman
Inouye, Sharon K.
Dickerson, Bradford C.
Touroutoglou, Alexandra
Collins, Jessica A.
author_sort Katsumi, Yuta
collection PubMed
description Major surgery is associated with a systemic inflammatory cascade that is thought, in some cases, to contribute to transient and/or sustained cognitive decline, possibly through neuroinflammatory mechanisms. However, the relationship between surgery, peripheral and central nervous system inflammation, and post-operative cognitive outcomes remains unclear in humans, primarily owing to limitations of in vivo biomarkers of neuroinflammation which vary in sensitivity, specificity, validity, and reliability. In the present study, [(11)C]PBR28 positron emission tomography, cerebrospinal fluid (CSF), and blood plasma biomarkers of inflammation were assessed pre-operatively and 1-month post-operatively in a cohort of patients (N = 36; 30 females; ≥70 years old) undergoing major orthopedic surgery under spinal anesthesia. Delirium incidence and severity were evaluated daily during hospitalization. Whole-brain voxel-wise and regions-of-interest analyses were performed to determine the magnitude and spatial extent of changes in [(11)C]PBR28 uptake following surgery. Results demonstrated that, compared with pre-operative baseline, [(11)C]PBR28 binding in the brain was globally downregulated at 1 month following major orthopedic surgery, possibly suggesting downregulation of the immune system of the brain. No significant relationship was identified between post-operative delirium and [(11)C]PBR28 binding, possibly due to a small number (n = 6) of delirium cases in the sample. Additionally, no significant relationships were identified between [(11)C]PBR28 binding and CSF/plasma biomarkers of inflammation. Collectively, these results contribute to the literature by demonstrating in a sizeable sample the effect of major surgery on neuroimmune activation and preliminary evidence identifying no apparent associations between [(11)C]PBR28 binding and fluid inflammatory markers or post-operative delirium.
format Online
Article
Text
id pubmed-7390821
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-73908212020-08-04 The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [(11)C]PBR28 binding and exploration of its link to post-operative delirium Katsumi, Yuta Racine, Annie M. Torrado-Carvajal, Angel Loggia, Marco L. Hooker, Jacob M. Greve, Douglas N. Hightower, Baileigh G. Catana, Ciprian Cavallari, Michele Arnold, Steven E. Fong, Tamara G. Vasunilashorn, Sarinnapha M. Marcantonio, Edward R. Schmitt, Eva M. Xu, Guoquan Libermann, Towia A. Barrett, Lisa Feldman Inouye, Sharon K. Dickerson, Bradford C. Touroutoglou, Alexandra Collins, Jessica A. Neuroimage Clin Regular Article Major surgery is associated with a systemic inflammatory cascade that is thought, in some cases, to contribute to transient and/or sustained cognitive decline, possibly through neuroinflammatory mechanisms. However, the relationship between surgery, peripheral and central nervous system inflammation, and post-operative cognitive outcomes remains unclear in humans, primarily owing to limitations of in vivo biomarkers of neuroinflammation which vary in sensitivity, specificity, validity, and reliability. In the present study, [(11)C]PBR28 positron emission tomography, cerebrospinal fluid (CSF), and blood plasma biomarkers of inflammation were assessed pre-operatively and 1-month post-operatively in a cohort of patients (N = 36; 30 females; ≥70 years old) undergoing major orthopedic surgery under spinal anesthesia. Delirium incidence and severity were evaluated daily during hospitalization. Whole-brain voxel-wise and regions-of-interest analyses were performed to determine the magnitude and spatial extent of changes in [(11)C]PBR28 uptake following surgery. Results demonstrated that, compared with pre-operative baseline, [(11)C]PBR28 binding in the brain was globally downregulated at 1 month following major orthopedic surgery, possibly suggesting downregulation of the immune system of the brain. No significant relationship was identified between post-operative delirium and [(11)C]PBR28 binding, possibly due to a small number (n = 6) of delirium cases in the sample. Additionally, no significant relationships were identified between [(11)C]PBR28 binding and CSF/plasma biomarkers of inflammation. Collectively, these results contribute to the literature by demonstrating in a sizeable sample the effect of major surgery on neuroimmune activation and preliminary evidence identifying no apparent associations between [(11)C]PBR28 binding and fluid inflammatory markers or post-operative delirium. Elsevier 2020-07-14 /pmc/articles/PMC7390821/ /pubmed/32712451 http://dx.doi.org/10.1016/j.nicl.2020.102346 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Katsumi, Yuta
Racine, Annie M.
Torrado-Carvajal, Angel
Loggia, Marco L.
Hooker, Jacob M.
Greve, Douglas N.
Hightower, Baileigh G.
Catana, Ciprian
Cavallari, Michele
Arnold, Steven E.
Fong, Tamara G.
Vasunilashorn, Sarinnapha M.
Marcantonio, Edward R.
Schmitt, Eva M.
Xu, Guoquan
Libermann, Towia A.
Barrett, Lisa Feldman
Inouye, Sharon K.
Dickerson, Bradford C.
Touroutoglou, Alexandra
Collins, Jessica A.
The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [(11)C]PBR28 binding and exploration of its link to post-operative delirium
title The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [(11)C]PBR28 binding and exploration of its link to post-operative delirium
title_full The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [(11)C]PBR28 binding and exploration of its link to post-operative delirium
title_fullStr The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [(11)C]PBR28 binding and exploration of its link to post-operative delirium
title_full_unstemmed The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [(11)C]PBR28 binding and exploration of its link to post-operative delirium
title_short The Role of Inflammation after Surgery for Elders (RISE) study: Examination of [(11)C]PBR28 binding and exploration of its link to post-operative delirium
title_sort role of inflammation after surgery for elders (rise) study: examination of [(11)c]pbr28 binding and exploration of its link to post-operative delirium
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390821/
https://www.ncbi.nlm.nih.gov/pubmed/32712451
http://dx.doi.org/10.1016/j.nicl.2020.102346
work_keys_str_mv AT katsumiyuta theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT racineanniem theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT torradocarvajalangel theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT loggiamarcol theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT hookerjacobm theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT grevedouglasn theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT hightowerbaileighg theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT catanaciprian theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT cavallarimichele theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT arnoldstevene theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT fongtamarag theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT vasunilashornsarinnapham theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT marcantonioedwardr theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT schmittevam theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT xuguoquan theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT libermanntowiaa theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT barrettlisafeldman theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT inouyesharonk theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT dickersonbradfordc theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT touroutogloualexandra theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT collinsjessicaa theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT theroleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT katsumiyuta roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT racineanniem roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT torradocarvajalangel roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT loggiamarcol roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT hookerjacobm roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT grevedouglasn roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT hightowerbaileighg roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT catanaciprian roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT cavallarimichele roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT arnoldstevene roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT fongtamarag roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT vasunilashornsarinnapham roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT marcantonioedwardr roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT schmittevam roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT xuguoquan roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT libermanntowiaa roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT barrettlisafeldman roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT inouyesharonk roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT dickersonbradfordc roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT touroutogloualexandra roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT collinsjessicaa roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium
AT roleofinflammationaftersurgeryforeldersrisestudyexaminationof11cpbr28bindingandexplorationofitslinktopostoperativedelirium