Cargando…
Identification of Clonal Neoantigens Derived From Driver Mutations in an EGFR-Mutated Lung Cancer Patient Benefitting From Anti-PD-1
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been recommended as the first-line therapy for non-small cell lung cancer (NSCLC) patients harboring EGFR mutations. However, acquired resistance to EGFR-TKIs is inevitable. Although immune checkpoint blockades (ICBs) tar...
Autores principales: | Wu, Di, Liu, Yangyang, Li, Xiaoting, Liu, Yiying, Yang, Qifan, Liu, Yuting, Wu, Jingjing, Tian, Chen, Zeng, Yulan, Zhao, Zhikun, Xiao, Yajie, Gu, Feifei, Zhang, Kai, Hu, Yue, Liu, Li |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390822/ https://www.ncbi.nlm.nih.gov/pubmed/32793190 http://dx.doi.org/10.3389/fimmu.2020.01366 |
Ejemplares similares
-
The Efficacy of First-Generation EGFR-TKI Combined With Brain
Radiotherapy as the First-Line Treatment for Lung Adenocarcinoma Patients With
Brain Metastases and EGFR Sensitive Mutations: A Retrospective
study
por: Liu, Yuting, et al.
Publicado: (2021) -
Identification of Novel HLA Class II-Restricted Neoantigens Derived from Driver Mutations
por: Iiizumi, Susumu, et al.
Publicado: (2019) -
Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response
por: Temko, Daniel, et al.
Publicado: (2018) -
Clonal Architectures and Driver Mutations in Metastatic Melanomas
por: Ding, Li, et al.
Publicado: (2014) -
Clinically significant sub-clonality for common drivers can be detected in 26% of KRAS/EGFR mutated lung adenocarcinomas
por: Simon, Einav, et al.
Publicado: (2017)