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HIV Reservoir Decay and CD4 Recovery Associated With High CD8 Counts in Immune Restored Patients on Long-Term ART

Background: Whether varying CD8 counts influence the human immunodeficiency virus (HIV) reservoir and CD4 restoration in patients with CD4 counts ≥ 500 cells/μL after long-term antiretroviral therapy (ART) remains unknown. In this study, we analyzed relationships between CD8 levels and viral reservo...

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Autores principales: Zhang, Lu-Xue, Jiao, Yan-Mei, Zhang, Chao, Song, Jin-Wen, Fan, Xing, Xu, Ruo-Nan, Huang, Hui-Huang, Zhang, Ji-Yuan, Wang, Li-Feng, Zhou, Chun-Bao, Jin, Lei, Shi, Ming, Wang, Fu-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390854/
https://www.ncbi.nlm.nih.gov/pubmed/32793212
http://dx.doi.org/10.3389/fimmu.2020.01541
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author Zhang, Lu-Xue
Jiao, Yan-Mei
Zhang, Chao
Song, Jin-Wen
Fan, Xing
Xu, Ruo-Nan
Huang, Hui-Huang
Zhang, Ji-Yuan
Wang, Li-Feng
Zhou, Chun-Bao
Jin, Lei
Shi, Ming
Wang, Fu-Sheng
author_facet Zhang, Lu-Xue
Jiao, Yan-Mei
Zhang, Chao
Song, Jin-Wen
Fan, Xing
Xu, Ruo-Nan
Huang, Hui-Huang
Zhang, Ji-Yuan
Wang, Li-Feng
Zhou, Chun-Bao
Jin, Lei
Shi, Ming
Wang, Fu-Sheng
author_sort Zhang, Lu-Xue
collection PubMed
description Background: Whether varying CD8 counts influence the human immunodeficiency virus (HIV) reservoir and CD4 restoration in patients with CD4 counts ≥ 500 cells/μL after long-term antiretroviral therapy (ART) remains unknown. In this study, we analyzed relationships between CD8 levels and viral reservoir decay or CD4 recovery in immune restored patients on long-term ART. Methods: Chronic HIV-infected patients who received 5 years of ART with CD4 counts ≥ 500 cells/μL were grouped according to CD8 counts: CD8 <500 (Group 1), 500–1,000 (Group 2), and ≥1,000 cells/μL (Group 3). CD4 recovery, viral decay, CD8 T-cell function, and their correlations were analyzed during ART among the three groups. Results: Dynamics of viral decay and CD4 recovery were different among the three groups. Both viral decay and CD4 recovery were higher in Group 3 than the other two groups after 5 years of ART, mainly during years 3–5 of ART. Higher expression levels of Ki67 while PD-1 levels were lower on CD8 T-cells in Group 3 compared with the other groups, and Group 3 showed stronger CD8 T-cells functional capacity after 3 years of ART. Reduced HIV DNA levels and increased CD4 counts between years 3 and 5 of ART were positively correlated with CD8 counts and function. Conclusions: High CD8 counts are beneficial for persistent viral decay and CD4 recovery in immune restored patients during long-term ART.
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spelling pubmed-73908542020-08-12 HIV Reservoir Decay and CD4 Recovery Associated With High CD8 Counts in Immune Restored Patients on Long-Term ART Zhang, Lu-Xue Jiao, Yan-Mei Zhang, Chao Song, Jin-Wen Fan, Xing Xu, Ruo-Nan Huang, Hui-Huang Zhang, Ji-Yuan Wang, Li-Feng Zhou, Chun-Bao Jin, Lei Shi, Ming Wang, Fu-Sheng Front Immunol Immunology Background: Whether varying CD8 counts influence the human immunodeficiency virus (HIV) reservoir and CD4 restoration in patients with CD4 counts ≥ 500 cells/μL after long-term antiretroviral therapy (ART) remains unknown. In this study, we analyzed relationships between CD8 levels and viral reservoir decay or CD4 recovery in immune restored patients on long-term ART. Methods: Chronic HIV-infected patients who received 5 years of ART with CD4 counts ≥ 500 cells/μL were grouped according to CD8 counts: CD8 <500 (Group 1), 500–1,000 (Group 2), and ≥1,000 cells/μL (Group 3). CD4 recovery, viral decay, CD8 T-cell function, and their correlations were analyzed during ART among the three groups. Results: Dynamics of viral decay and CD4 recovery were different among the three groups. Both viral decay and CD4 recovery were higher in Group 3 than the other two groups after 5 years of ART, mainly during years 3–5 of ART. Higher expression levels of Ki67 while PD-1 levels were lower on CD8 T-cells in Group 3 compared with the other groups, and Group 3 showed stronger CD8 T-cells functional capacity after 3 years of ART. Reduced HIV DNA levels and increased CD4 counts between years 3 and 5 of ART were positively correlated with CD8 counts and function. Conclusions: High CD8 counts are beneficial for persistent viral decay and CD4 recovery in immune restored patients during long-term ART. Frontiers Media S.A. 2020-07-23 /pmc/articles/PMC7390854/ /pubmed/32793212 http://dx.doi.org/10.3389/fimmu.2020.01541 Text en Copyright © 2020 Zhang, Jiao, Zhang, Song, Fan, Xu, Huang, Zhang, Wang, Zhou, Jin, Shi and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Lu-Xue
Jiao, Yan-Mei
Zhang, Chao
Song, Jin-Wen
Fan, Xing
Xu, Ruo-Nan
Huang, Hui-Huang
Zhang, Ji-Yuan
Wang, Li-Feng
Zhou, Chun-Bao
Jin, Lei
Shi, Ming
Wang, Fu-Sheng
HIV Reservoir Decay and CD4 Recovery Associated With High CD8 Counts in Immune Restored Patients on Long-Term ART
title HIV Reservoir Decay and CD4 Recovery Associated With High CD8 Counts in Immune Restored Patients on Long-Term ART
title_full HIV Reservoir Decay and CD4 Recovery Associated With High CD8 Counts in Immune Restored Patients on Long-Term ART
title_fullStr HIV Reservoir Decay and CD4 Recovery Associated With High CD8 Counts in Immune Restored Patients on Long-Term ART
title_full_unstemmed HIV Reservoir Decay and CD4 Recovery Associated With High CD8 Counts in Immune Restored Patients on Long-Term ART
title_short HIV Reservoir Decay and CD4 Recovery Associated With High CD8 Counts in Immune Restored Patients on Long-Term ART
title_sort hiv reservoir decay and cd4 recovery associated with high cd8 counts in immune restored patients on long-term art
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390854/
https://www.ncbi.nlm.nih.gov/pubmed/32793212
http://dx.doi.org/10.3389/fimmu.2020.01541
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