Cargando…

HIV Reservoir Decay and CD4 Recovery Associated With High CD8 Counts in Immune Restored Patients on Long-Term ART

Background: Whether varying CD8 counts influence the human immunodeficiency virus (HIV) reservoir and CD4 restoration in patients with CD4 counts ≥ 500 cells/μL after long-term antiretroviral therapy (ART) remains unknown. In this study, we analyzed relationships between CD8 levels and viral reservo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Lu-Xue, Jiao, Yan-Mei, Zhang, Chao, Song, Jin-Wen, Fan, Xing, Xu, Ruo-Nan, Huang, Hui-Huang, Zhang, Ji-Yuan, Wang, Li-Feng, Zhou, Chun-Bao, Jin, Lei, Shi, Ming, Wang, Fu-Sheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390854/ https://www.ncbi.nlm.nih.gov/pubmed/32793212 http://dx.doi.org/10.3389/fimmu.2020.01541

Ejemplares similares

CD8(+) lymphocytes do not impact SIV reservoir establishment under ART
por: Statzu, Maura, et al.
Publicado: (2023)

CD4/CD8 ratio and CD8 counts predict CD4 response in HIV-1-infected drug naive and in patients on cART
por: Sauter, Rafael, et al.
Publicado: (2016)

HIV-1-Specific CD11c(+) CD8(+) T Cells Display Low PD-1 Expression and Strong Anti-HIV-1 Activity
por: Guo, An-Liang, et al.
Publicado: (2021)

Thymosin Alpha-1 Has no Beneficial Effect on Restoring CD4+ and CD8+ T Lymphocyte Counts in COVID-19 Patients
por: Wang, Zhenyan, et al.
Publicado: (2021)

CCL5-Secreting Virtual Memory CD8+ T Cells Inversely Associate With Viral Reservoir Size in HIV‐1−Infected Individuals on Antiretroviral Therapy
por: Hu, Wei, et al.
Publicado: (2022)

Expression of CD39 Is Correlated With HIV DNA Levels in Naïve Tregs in Chronically Infected ART Naïve Patients
por: Song, Jin-Wen, et al.
Publicado: (2019)

Long terms trends in CD4(+) cell counts, CD8(+) cell counts, and the CD4(+) : CD8(+) ratio
por: Hughes, Rachael A., et al.
Publicado: (2018)

Peripheral blood CD4+ cell counts but not CD3+ and CD8+ cell counts are reduced in SARS-CoV-2 infection
por: Huang, Zhi-Xin, et al.
Publicado: (2020)

CD4+T, CD8+T counts and severe COVID-19: A meta-analysis
por: Zhang, Haipeng, et al.
Publicado: (2020)

Major influence of CD4 count at the initiation of cART on viral and immunological reservoir constitution in HIV-1 infected patients
por: Depincé-Berger, Anne-Emmanuelle, et al.
Publicado: (2016)

Absolute CD4(+) T cell count overstate immune recovery assessed by CD4(+)/CD8(+) ratio in HIV-infected patients on treatment
por: Milanés-Guisado, Yusnelkis, et al.
Publicado: (2018)

CD8+ cells and small viral reservoirs facilitate post-ART control of SIV in Mauritian cynomolgus macaques
por: Harwood, Olivia E., et al.
Publicado: (2023)

Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1–Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy
por: Gras, Luuk, et al.
Publicado: (2019)

CD4:CD8 Ratio and CD8 Count as Prognostic Markers for Mortality in Human Immunodeficiency Virus–Infected Patients on Antiretroviral Therapy: The Antiretroviral Therapy Cohort Collaboration (ART-CC)
por: Trickey, Adam, et al.
Publicado: (2017)

Combining CD4 recovery and CD4: CD8 ratio restoration as an indicator for evaluating the outcome of continued antiretroviral therapy: an observational cohort study
por: Lee, Shui Shan, et al.
Publicado: (2017)

High CD45 expression of CD8+ and CD4+ T cells correlates with the size of HIV-1 reservoir in blood
por: Petkov, Stefan, et al.
Publicado: (2020)

Reversal of the CD8(+) T-Cell Exhaustion Induced by Chronic HIV-1 Infection Through Combined Blockade of the Adenosine and PD-1 Pathways
por: Li, Jing, et al.
Publicado: (2021)

Lymphocyte subset (CD4+, CD8+) counts reflect the severity of infection and predict the clinical outcomes in patients with COVID-19
por: Liu, Zeming, et al.
Publicado: (2020)

Counting CD4(+) and CD8(+) T cells in the spleen: a novel in vivo method for assessing biomaterial immunotoxicity
por: Shieh, Shyh-Jou, et al.
Publicado: (2014)

Subdividing ART patients and analyzing the medical burden by modeling of CD4 cell count
por: Min, Li, et al.
Publicado: (2023)

Low Double-Negative CD3(+)CD4(−)CD8(−) T Cells Are Associated with Incomplete Restoration of CD4(+) T Cells and Higher Immune Activation in HIV-1 Immunological Non-Responders
por: Lu, Xiaofan, et al.
Publicado: (2016)

Epitope-dependent effect of long-term cART on maintenance and recovery of HIV-1-specific CD8(+) T cells
por: Kuse, Nozomi, et al.
Publicado: (2023)

Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ART
por: Jiao, Yanmei, et al.
Publicado: (2011)

Statistical Analysis and Evaluation of CD4 Count after 6 Months on ART
por: Mrudula, N Dravid, et al.
Publicado: (2012)

An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8(+) T cell magnitude and short-lived differentiation status
por: Takata, Hiroshi, et al.
Publicado: (2023)

ELISPOTs Produced by CD8 and CD4 Cells Follow Log Normal Size Distribution Permitting Objective Counting
por: Karulin, Alexey Y., et al.
Publicado: (2015)

Decreased CD8(+)CD28(+)/CD8(+)CD28(–) T cell ratio can sensitively predict poor outcome for patients with complicated Crohn disease
por: Dai, Shi-xue, et al.
Publicado: (2017)

Rapid Recovery of CD3(+)CD8(+) T Cells on Day 90 Predicts Superior Survival after Unmanipulated Haploidentical Blood and Marrow Transplantation
por: Tian, Deng-Mei, et al.
Publicado: (2016)

Restoring Cytokine Balance in HIV-Positive Individuals with Low CD4 T Cell Counts
por: Valdivia, Anddre, et al.
Publicado: (2017)

CD4+ cell count recovery in naïve patients initiating cART, who achieved and maintained plasma HIV-RNA suppression
por: Costagliola, Dominique, et al.
Publicado: (2014)

CD4 cell count and CD4/CD8 ratio increase during rituximab maintenance in granulomatosis with polyangiitis patients
por: Besada, Emilio, et al.
Publicado: (2016)

Oral Kaposi sarcoma development is associated with HIV viral load, CD4+ count and CD4+/CD8+ ratio
por: de Sousa, Rosa Hiolanda Abreu, et al.
Publicado: (2021)

CD4+ and CD8+ cell counts are significantly correlated with absolute lymphocyte count in hospitalized COVID-19 patients: a retrospective study
por: Liana, Phey, et al.
Publicado: (2023)

Determinants of CD4 count and risk for death of HIV infected children under ART
por: Gwadu, Ayitenew Agegn, et al.
Publicado: (2022)

CD3(+)T, CD4(+)T, CD8(+)T, and CD4(+)T/CD8(+)T Ratio and Quantity of γδT Cells in Peripheral Blood of HIV-Infected/AIDS Patients and Its Clinical Significance
por: Zhao, Nange, et al.
Publicado: (2021)

Regulation of CD4(+)CD8(−)CD25(+) and CD4(+)CD8(+)CD25(+) T cells by gut microbiota in chicken
por: Lee, In Kyu, et al.
Publicado: (2018)

Changes in intestinal microbiota in HIV-1-infected subjects following cART initiation: influence of CD4+ T cell count
por: Ji, Yongjia, et al.
Publicado: (2018)

Dichotomous Roles of Programmed Cell Death 1 on HIV-Specific CXCR5(+) and CXCR5(−) CD8(+) T Cells during Chronic HIV Infection
por: Jiao, Yan-Mei, et al.
Publicado: (2017)

The grace of aging with ART: Ex vivo dendritic cell-based immunotherapy restores HIV-specific functional CD8(+) T-cells
por: Mehraj, Vikram, et al.
Publicado: (2022)

Predictive value of CD8+ T cell and CD4/CD8 ratio at two years of successful ART in the risk of AIDS and non-AIDS events
por: Serrano-Villar, Sergio, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t10k3q8dg44hbg8rb3k8ctlchn