Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma

Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance. 10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurren...

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Detalles Bibliográficos
Autores principales: Hamdaoui, Hasna, Natiq, Abdelhafid, Benlarroubia, Oumaima, Liehr, Thomas, Dehbi, Hind, Loukhmas, Latifa, Chegdani, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390876/
https://www.ncbi.nlm.nih.gov/pubmed/32760648
http://dx.doi.org/10.1016/j.lrr.2020.100217
Descripción
Sumario:Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance. 10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurrent multiple myeloma. This study of MM case in which we found a near tetraploid complex karyotype with the t(11;14) (q13;q32) abnormality in cytogenetic analysis and the presence of t(4;14) and del(17p) by iFISH, referred to several studies which showed the translocation t(11;14) as the most frequent abnormality in both AL amyloidosis and MM.

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