Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma

Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance. 10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurren...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamdaoui, Hasna, Natiq, Abdelhafid, Benlarroubia, Oumaima, Liehr, Thomas, Dehbi, Hind, Loukhmas, Latifa, Chegdani, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390876/
https://www.ncbi.nlm.nih.gov/pubmed/32760648
http://dx.doi.org/10.1016/j.lrr.2020.100217
_version_ 1783564533222080512
author Hamdaoui, Hasna
Natiq, Abdelhafid
Benlarroubia, Oumaima
Liehr, Thomas
Dehbi, Hind
Loukhmas, Latifa
Chegdani, Fatima
author_facet Hamdaoui, Hasna
Natiq, Abdelhafid
Benlarroubia, Oumaima
Liehr, Thomas
Dehbi, Hind
Loukhmas, Latifa
Chegdani, Fatima
author_sort Hamdaoui, Hasna
collection PubMed
description Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance. 10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurrent multiple myeloma. This study of MM case in which we found a near tetraploid complex karyotype with the t(11;14) (q13;q32) abnormality in cytogenetic analysis and the presence of t(4;14) and del(17p) by iFISH, referred to several studies which showed the translocation t(11;14) as the most frequent abnormality in both AL amyloidosis and MM.
format Online
Article
Text
id pubmed-7390876
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-73908762020-08-04 Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma Hamdaoui, Hasna Natiq, Abdelhafid Benlarroubia, Oumaima Liehr, Thomas Dehbi, Hind Loukhmas, Latifa Chegdani, Fatima Leuk Res Rep Article Cytogenetic and iFISH plays a major part in the diagnosis of the MM and have an important prognostic significance. 10–15% of patients with amyloidosis will also have multiple myeloma (MM). Few studies have addressed the clinical and cytogenetic features of patients with AL amyloidosis with concurrent multiple myeloma. This study of MM case in which we found a near tetraploid complex karyotype with the t(11;14) (q13;q32) abnormality in cytogenetic analysis and the presence of t(4;14) and del(17p) by iFISH, referred to several studies which showed the translocation t(11;14) as the most frequent abnormality in both AL amyloidosis and MM. Elsevier 2020-07-22 /pmc/articles/PMC7390876/ /pubmed/32760648 http://dx.doi.org/10.1016/j.lrr.2020.100217 Text en © 2020 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Hamdaoui, Hasna
Natiq, Abdelhafid
Benlarroubia, Oumaima
Liehr, Thomas
Dehbi, Hind
Loukhmas, Latifa
Chegdani, Fatima
Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title_full Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title_fullStr Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title_full_unstemmed Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title_short Near tetrapoloid karyotype with translocation t(11;14) in a Moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
title_sort near tetrapoloid karyotype with translocation t(11;14) in a moroccan patient with amyloid light-chain amyloidosis and multiple myeloma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390876/
https://www.ncbi.nlm.nih.gov/pubmed/32760648
http://dx.doi.org/10.1016/j.lrr.2020.100217
work_keys_str_mv AT hamdaouihasna neartetrapoloidkaryotypewithtranslocationt1114inamoroccanpatientwithamyloidlightchainamyloidosisandmultiplemyeloma
AT natiqabdelhafid neartetrapoloidkaryotypewithtranslocationt1114inamoroccanpatientwithamyloidlightchainamyloidosisandmultiplemyeloma
AT benlarroubiaoumaima neartetrapoloidkaryotypewithtranslocationt1114inamoroccanpatientwithamyloidlightchainamyloidosisandmultiplemyeloma
AT liehrthomas neartetrapoloidkaryotypewithtranslocationt1114inamoroccanpatientwithamyloidlightchainamyloidosisandmultiplemyeloma
AT dehbihind neartetrapoloidkaryotypewithtranslocationt1114inamoroccanpatientwithamyloidlightchainamyloidosisandmultiplemyeloma
AT loukhmaslatifa neartetrapoloidkaryotypewithtranslocationt1114inamoroccanpatientwithamyloidlightchainamyloidosisandmultiplemyeloma
AT chegdanifatima neartetrapoloidkaryotypewithtranslocationt1114inamoroccanpatientwithamyloidlightchainamyloidosisandmultiplemyeloma

Ejemplares similares