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The GTPase Domain of MX2 Interacts with the HIV-1 Capsid, Enabling Its Short Isoform to Moderate Antiviral Restriction

Myxovirus resistance 2 (MX2/MXB) is an interferon (IFN)-induced HIV-1 restriction factor that inhibits viral nuclear DNA accumulation. The amino-terminal domain of MX2 binds the viral capsid and is essential for inhibition. Using in vitro assembled Capsid-Nucleocapsid (CANC) complexes as a surrogate...

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Detalles Bibliográficos
Autores principales:	Betancor, Gilberto, Dicks, Matthew D.J., Jimenez-Guardeño, Jose M., Ali, Nabil H., Apolonia, Luis, Malim, Michael H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391006/ https://www.ncbi.nlm.nih.gov/pubmed/31722207 http://dx.doi.org/10.1016/j.celrep.2019.10.009

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