Cargando…

IL10-modified Human Mesenchymal Stem Cells inhibit Pancreatic Cancer growth through Angiogenesis Inhibition

In the present study, we constructed the recombinant plasmid IL10-PEGFP-C1 and successfully transfected into human mesenchymal stem cells. After culturing for 72 h, the levels of IL6 and TNF-α in the supernatant of the MSCs-IL10 group were significantly lower than the vector group and the control gr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Chunyan, Pu, Yu, Zhang, Haidi, Hu, Xianhua, Zhang, Rendan, He, Shuai, Zhao, Qi, Mu, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391191/ https://www.ncbi.nlm.nih.gov/pubmed/32742480 http://dx.doi.org/10.7150/jca.38062

Ejemplares similares

Wild-type KRAS inhibits the migration and invasion of pancreatic cancer through the Wnt/β-catenin pathway
por: Hu, Xianhua, et al.
Publicado: (2022)

Effect of F11R Gene Knockdown on Malignant Biological Behaviors of Pancreatic Cancer Cells
por: Zhang, HaiDi, et al.
Publicado: (2022)

Potential applications of prognostic and immunological marker transmembrane serine proteinase 2 in prediction, prevention and personalized treatment of lung cancer
por: Mu, Bo, et al.
Publicado: (2022)

An IP-10 (CXCL10)-Derived Peptide Inhibits Angiogenesis
por: Yates-Binder, Cecelia C., et al.
Publicado: (2012)

Hypoxia-Mesenchymal Stem Cells Inhibit Intra-Peritoneal Adhesions Formation by Upregulation of the IL-10 Expression
por: Muhar, Adi Muradi, et al.
Publicado: (2019)

Spontaneous colitis in IL‐10‐deficient mice was ameliorated via inhibiting glutaminase1
por: Li, Jing, et al.
Publicado: (2019)

10Z-Hymenialdisine inhibits angiogenesis by suppressing NF-κB activation in pancreatic cancer cell lines
por: Ueda, Goro, et al.
Publicado: (2022)

IL-17 Inhibits Chondrogenic Differentiation of Human Mesenchymal Stem Cells
por: Kondo, Masahiro, et al.
Publicado: (2013)

Galangin inhibits epithelial-mesenchymal transition and angiogenesis by downregulating CD44 in glioma
por: Chen, Daliang, et al.
Publicado: (2019)

Nintedanib attenuates peritoneal fibrosis by inhibiting mesothelial‐to‐mesenchymal transition, inflammation and angiogenesis
por: Liu, Feng, et al.
Publicado: (2021)

Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells
por: Yu, Dinglai, et al.
Publicado: (2017)

VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma
por: Beckermann, B M, et al.
Publicado: (2008)

IL-4 modified expanded polytetrafluoroethylene (e-PTFE) surgical patch promotes angiogenesis in transplanted flap and inhibits inflammatory response
por: Song, Peng, et al.
Publicado: (2023)

Curcumin induces apoptosis and inhibits angiogenesis in murine malignant mesothelioma
por: Zhang, Chengke, et al.
Publicado: (2018)

Metformin Inhibits the IL-6-Induced Epithelial-Mesenchymal Transition and Lung Adenocarcinoma Growth and Metastasis
por: Zhao, Zhongquan, et al.
Publicado: (2014)

Mesenchymal stem cells genetically modified by lentivirus-mediated interleukin-12 inhibit malignant ascites in mice
por: HAN, JIMING, et al.
Publicado: (2014)

Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas
por: Carew, Jennifer S., et al.
Publicado: (2017)

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes
Publicado: (1991)

Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells
por: Yao, Yongxue, et al.
Publicado: (2005)

Dual-Ligand-Modified Liposomes Co-Loaded with Anti-Angiogenic and Chemotherapeutic Drugs for Inhibiting Tumor Angiogenesis and Metastasis
por: Wang, Fangqing, et al.
Publicado: (2021)

Apoptin-modified human mesenchymal stem cells inhibit growth of lung carcinoma in nude mice
por: DU, JINGCHUN, et al.
Publicado: (2015)

Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6
por: Yi, Huan, et al.
Publicado: (2021)

Treatment of Type II Collagen-Induced Rat Rheumatoid Arthritis Model by Interleukin 10 (IL10)-Mesenchymal Stem Cells (BMSCs)
por: Tian, Shuai, et al.
Publicado: (2019)

Knockout of EGFL6 by CRISPR/Cas9 Mediated Inhibition of Tumor Angiogenesis in Ovarian Cancer
por: Zhu, Wenhui, et al.
Publicado: (2020)

Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone
por: Ji, Baochao, et al.
Publicado: (2018)

Bone marrow-derived mesenchymal stem cells ameliorate severe acute pancreatitis by inhibiting oxidative stress in rats
por: Zhao, Dongbo, et al.
Publicado: (2022)

The Design, Characterizations, and Tumor Angiogenesis Inhibition of a Multi-Epitope Peptibody With bFGF/VEGFA
por: Zhang, Ligang, et al.
Publicado: (2020)

The Human IL-23 Decoy Receptor Inhibits T-Cells Producing IL-17 by Genetically Engineered Mesenchymal Stem Cells
por: Rostami, Masoumeh, et al.
Publicado: (2018)

Pristimerin, a Triterpenoid, Inhibits Tumor Angiogenesis by Targeting VEGFR2 Activation
por: Mu, Xianmin, et al.
Publicado: (2012)

Overexpression of microRNA-202-3p in bone marrow mesenchymal stem cells improves cerebral ischemia-reperfusion injury by promoting angiogenesis and inhibiting inflammation
por: Yu, Guohua, et al.
Publicado: (2021)

Bone marrow-derived mesenchymal stem cell-secreted IL-8 promotes the angiogenesis and growth of colorectal cancer
por: Wang, Jiancheng, et al.
Publicado: (2015)

Combination curcumin and (−)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway
por: Jin, G, et al.
Publicado: (2017)

Inhibition of Angiogenesis by Interleukin 4
por: Volpert, Olga V., et al.
Publicado: (1998)

Curcumin Inhibits Tumor Growth and Angiogenesis in an Orthotopic Mouse Model of Human Pancreatic Cancer
por: Bimonte, Sabrina, et al.
Publicado: (2013)

Xanthohumol inhibits angiogenesis by suppressing nuclear factor‐κB activation in pancreatic cancer
por: Saito, Kenta, et al.
Publicado: (2017)

IL-10 Gene-Modified Human Amniotic Mesenchymal Stem Cells Augment Regenerative Wound Healing by Multiple Synergistic Effects
por: Xiao, Shune, et al.
Publicado: (2019)

Naringenin Decreases Invasiveness and Metastasis by Inhibiting TGF-β-Induced Epithelial to Mesenchymal Transition in Pancreatic Cancer Cells
por: Lou, Changjie, et al.
Publicado: (2012)

Inhibition of KCTD10 Affects Diabetic Retinopathy Progression by Reducing VEGF and Affecting Angiogenesis
por: Feng, Yun, et al.
Publicado: (2022)

Fingolimod inhibits proliferation and epithelial–mesenchymal transition in sacral chordoma by inactivating IL-6/STAT3 signalling
por: Wang, Jiaqi, et al.
Publicado: (2020)

Pseudolaric Acid B Inhibits Proliferation, Invasion and Epithelial-to-Mesenchymal Transition in Human Pancreatic Cancer Cell
por: Li, Xiaoyu, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ntn4q9fm0pmmp7f7gjbhil3kll