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Isoprenylcysteine carboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal

Cancer stem cells possess the capacity for self-renewal and resistance to chemotherapy. It is therefore crucial to understand the molecular regulators of stemness in the quest to develop effective cancer therapies. TAZ is a transcription activator that promotes stem cell functions in post-developmen...

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Detalles Bibliográficos
Autores principales:	Chai, Tin Fan, Manu, Kanjoormana Aryan, Casey, Patrick J., Wang, Mei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391290/ https://www.ncbi.nlm.nih.gov/pubmed/32561852 http://dx.doi.org/10.1038/s41388-020-1364-7

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