Targeting fibroblast activation protein (FAP): next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA(5m) chelators

BACKGROUND: Fibroblast activation protein (FAP) is a proline selective serine protease that is overexpressed in tumor stroma and in lesions of many other diseases that are characterized by tissue remodeling. In 2014, a most potent FAP-inhibitor (referred to as UAMC1110) with low nanomolar FAP-affini...

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Detalles Bibliográficos
Autores principales: Moon, Euy Sung, Elvas, Filipe, Vliegen, Gwendolyn, De Lombaerde, Stef, Vangestel, Christel, De Bruycker, Sven, Bracke, An, Eppard, Elisabeth, Greifenstein, Lukas, Klasen, Benedikt, Kramer, Vasko, Staelens, Steven, De Meester, Ingrid, Van der Veken, Pieter, Rösch, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391456/
https://www.ncbi.nlm.nih.gov/pubmed/32728930
http://dx.doi.org/10.1186/s41181-020-00102-z

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