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Atherosclerotic plaque locations may be related to different ischemic lesion patterns
BACKGROUND: Atherosclerosis of the internal carotid artery (ICA) is an important cause of ischemic stroke. Artery-to-artery embolism is the major stroke mechanism in patients with atherosclerotic carotid disease. This study hypothesized that the atherosclerotic ICA geometry and plaque location would...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391573/ https://www.ncbi.nlm.nih.gov/pubmed/32731859 http://dx.doi.org/10.1186/s12883-020-01868-0 |
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author | Woo, Ho Geol Heo, Sung Hyuk Kim, Eui Jong Chang, Dae-il Song, Tae Jin Kim, Bum Joon |
author_facet | Woo, Ho Geol Heo, Sung Hyuk Kim, Eui Jong Chang, Dae-il Song, Tae Jin Kim, Bum Joon |
author_sort | Woo, Ho Geol |
collection | PubMed |
description | BACKGROUND: Atherosclerosis of the internal carotid artery (ICA) is an important cause of ischemic stroke. Artery-to-artery embolism is the major stroke mechanism in patients with atherosclerotic carotid disease. This study hypothesized that the atherosclerotic ICA geometry and plaque location would be associated with lesion pattern in patients with acute ischemic stroke. METHODS: Ischemic stroke patients with symptomatic proximal ICA disease (> 50% diameter stenosis) were enrolled. The carotid plaque location was divided into high-apical and low-body types. The geometric parameters of the ICA (angles between arteries) were measured, and ischemic lesion patterns were classified according to the number, location, and size of the lesions. Factors associated with plaque location and lesion pattern, dichotomized by size, were investigated. RESULTS: Of the 93 acute ischemic stroke patients enrolled, 31 had high-apical and 62 had low-body plaques. Hyperlipidemia was more prevalent and the common carotid artery (CCA)-ICA angle was wider (167.7 ± 10.4° vs 162.3 ± 9.8°, p = 0.019) in patients with low-body than high-apical plaques. Low-body plaques were more frequently associated with small scattered or cortical lesions (54.8% vs. 32.3%, p = 0.040), whereas high-apical plaques were more frequently associated with large lesions having additional lesions (38.7% vs. 11.3%, p = 0.002). The presence of low-body plaques (odds ratio: 3.106, 95% confidence interval: 1.105–8.728, p = 0.032) was independently associated with the small lesion-only pattern. CONCLUSIONS: Low-body plaques are more frequently associated with small scattered lesions, whereas high-apical plaques are more frequently associated with large lesions having additional lesions. A wide CCA-ICA angle is associated with low-body plaque of the carotid artery. |
format | Online Article Text |
id | pubmed-7391573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73915732020-07-31 Atherosclerotic plaque locations may be related to different ischemic lesion patterns Woo, Ho Geol Heo, Sung Hyuk Kim, Eui Jong Chang, Dae-il Song, Tae Jin Kim, Bum Joon BMC Neurol Research Article BACKGROUND: Atherosclerosis of the internal carotid artery (ICA) is an important cause of ischemic stroke. Artery-to-artery embolism is the major stroke mechanism in patients with atherosclerotic carotid disease. This study hypothesized that the atherosclerotic ICA geometry and plaque location would be associated with lesion pattern in patients with acute ischemic stroke. METHODS: Ischemic stroke patients with symptomatic proximal ICA disease (> 50% diameter stenosis) were enrolled. The carotid plaque location was divided into high-apical and low-body types. The geometric parameters of the ICA (angles between arteries) were measured, and ischemic lesion patterns were classified according to the number, location, and size of the lesions. Factors associated with plaque location and lesion pattern, dichotomized by size, were investigated. RESULTS: Of the 93 acute ischemic stroke patients enrolled, 31 had high-apical and 62 had low-body plaques. Hyperlipidemia was more prevalent and the common carotid artery (CCA)-ICA angle was wider (167.7 ± 10.4° vs 162.3 ± 9.8°, p = 0.019) in patients with low-body than high-apical plaques. Low-body plaques were more frequently associated with small scattered or cortical lesions (54.8% vs. 32.3%, p = 0.040), whereas high-apical plaques were more frequently associated with large lesions having additional lesions (38.7% vs. 11.3%, p = 0.002). The presence of low-body plaques (odds ratio: 3.106, 95% confidence interval: 1.105–8.728, p = 0.032) was independently associated with the small lesion-only pattern. CONCLUSIONS: Low-body plaques are more frequently associated with small scattered lesions, whereas high-apical plaques are more frequently associated with large lesions having additional lesions. A wide CCA-ICA angle is associated with low-body plaque of the carotid artery. BioMed Central 2020-07-30 /pmc/articles/PMC7391573/ /pubmed/32731859 http://dx.doi.org/10.1186/s12883-020-01868-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Woo, Ho Geol Heo, Sung Hyuk Kim, Eui Jong Chang, Dae-il Song, Tae Jin Kim, Bum Joon Atherosclerotic plaque locations may be related to different ischemic lesion patterns |
title | Atherosclerotic plaque locations may be related to different ischemic lesion patterns |
title_full | Atherosclerotic plaque locations may be related to different ischemic lesion patterns |
title_fullStr | Atherosclerotic plaque locations may be related to different ischemic lesion patterns |
title_full_unstemmed | Atherosclerotic plaque locations may be related to different ischemic lesion patterns |
title_short | Atherosclerotic plaque locations may be related to different ischemic lesion patterns |
title_sort | atherosclerotic plaque locations may be related to different ischemic lesion patterns |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391573/ https://www.ncbi.nlm.nih.gov/pubmed/32731859 http://dx.doi.org/10.1186/s12883-020-01868-0 |
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