Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence

Advanced and recurrent gynecological cancers are associated with poor prognosis and lack of effective treatment. The developments of the molecular mechanisms on cancer progression provide insight into novel targeted therapies, which are emerging as groundbreaking and promising cancer treatment strat...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Qiao, Peng, Hongling, Qi, Xiaorong, Wu, Min, Zhao, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391668/
https://www.ncbi.nlm.nih.gov/pubmed/32728057
http://dx.doi.org/10.1038/s41392-020-0199-6
_version_ 1783564693269381120
author Wang, Qiao
Peng, Hongling
Qi, Xiaorong
Wu, Min
Zhao, Xia
author_facet Wang, Qiao
Peng, Hongling
Qi, Xiaorong
Wu, Min
Zhao, Xia
author_sort Wang, Qiao
collection PubMed
description Advanced and recurrent gynecological cancers are associated with poor prognosis and lack of effective treatment. The developments of the molecular mechanisms on cancer progression provide insight into novel targeted therapies, which are emerging as groundbreaking and promising cancer treatment strategies. In gynecologic malignancies, potential therapeutic targeted agents include antiangiogenic agents, poly (ADP-ribose) polymerase (PARP) inhibitors, tumor-intrinsic signaling pathway inhibitors, selective estrogen receptor downregulators, and immune checkpoint inhibitors. In this article, we provide a comprehensive review of the clinical evidence of targeted agents in gynecological cancers and discuss the future implication.
format Online
Article
Text
id pubmed-7391668
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-73916682020-08-12 Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence Wang, Qiao Peng, Hongling Qi, Xiaorong Wu, Min Zhao, Xia Signal Transduct Target Ther Review Article Advanced and recurrent gynecological cancers are associated with poor prognosis and lack of effective treatment. The developments of the molecular mechanisms on cancer progression provide insight into novel targeted therapies, which are emerging as groundbreaking and promising cancer treatment strategies. In gynecologic malignancies, potential therapeutic targeted agents include antiangiogenic agents, poly (ADP-ribose) polymerase (PARP) inhibitors, tumor-intrinsic signaling pathway inhibitors, selective estrogen receptor downregulators, and immune checkpoint inhibitors. In this article, we provide a comprehensive review of the clinical evidence of targeted agents in gynecological cancers and discuss the future implication. Nature Publishing Group UK 2020-07-29 /pmc/articles/PMC7391668/ /pubmed/32728057 http://dx.doi.org/10.1038/s41392-020-0199-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Wang, Qiao
Peng, Hongling
Qi, Xiaorong
Wu, Min
Zhao, Xia
Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
title Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
title_full Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
title_fullStr Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
title_full_unstemmed Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
title_short Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
title_sort targeted therapies in gynecological cancers: a comprehensive review of clinical evidence
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391668/
https://www.ncbi.nlm.nih.gov/pubmed/32728057
http://dx.doi.org/10.1038/s41392-020-0199-6
work_keys_str_mv AT wangqiao targetedtherapiesingynecologicalcancersacomprehensivereviewofclinicalevidence
AT penghongling targetedtherapiesingynecologicalcancersacomprehensivereviewofclinicalevidence
AT qixiaorong targetedtherapiesingynecologicalcancersacomprehensivereviewofclinicalevidence
AT wumin targetedtherapiesingynecologicalcancersacomprehensivereviewofclinicalevidence
AT zhaoxia targetedtherapiesingynecologicalcancersacomprehensivereviewofclinicalevidence

Ejemplares similares