Pre-clinical studies of EC2629, a highly potent folate- receptor-targeted DNA crosslinking agent

Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456. In our effort to develop FR-targeted SMDCs with varying mechanisms of action, we synthesized EC2629,...

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Detalles Bibliográficos
Autores principales: Reddy, Joseph A., Nelson, Melissa, Dircksen, Christina, Vetzel, Marilynn, Johnson, Theresa, Cross, Vicky, Westrick, Elaine, Qi, LongWu, Hahn, Spencer, Santhapuram, Hari Krishna, Parham, Garth, Wang, Kevin, Vaughn, Jeremy F., Felten, Albert, Pugh, Michael, Lu, June, Klein, Patrick, Vlahov, Iontcho R., Leamon, Christopher P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391724/
https://www.ncbi.nlm.nih.gov/pubmed/32728172
http://dx.doi.org/10.1038/s41598-020-69682-9

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