Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel

Menthol in mints elicits coolness sensation by selectively activating TRPM8 channel. Although structures of TRPM8 were determined in the apo and liganded states, the menthol-bounded state is unresolved. To understand how menthol activates the channel, we docked menthol to the channel and systematica...

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Detalles Bibliográficos
Autores principales: Xu, Lizhen, Han, Yalan, Chen, Xiaoying, Aierken, Aerziguli, Wen, Han, Zheng, Wenjun, Wang, Hongkun, Lu, Xiancui, Zhao, Zhenye, Ma, Cheng, Liang, Ping, Yang, Wei, Yang, Shilong, Yang, Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391767/
https://www.ncbi.nlm.nih.gov/pubmed/32728032
http://dx.doi.org/10.1038/s41467-020-17582-x

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