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Development of diffuse large B-cell lymphoma after sofosbuvir-ledipasvir treatment for chronic hepatitis C: A case report and literature review
Recently, treatments for chronic hepatitis C virus (HCV) infection have significantly improved by the development of direct-acting antiviral agents (DAAs) and almost all patients with HCV can complete antiviral treatment without apparent adverse events. Malignant lymphoma, particularly B-cell non-Ho...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391802/ https://www.ncbi.nlm.nih.gov/pubmed/32754315 http://dx.doi.org/10.3892/mco.2020.2071 |
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author | Sakai, Hiroyasu Miwa, Takao Ikoma, Yoshikazu Hanai, Tatsunori Nakamura, Nobuhiko Imai, Kenji Kitagawa, Junichi Shirakami, Yohei Kanemura, Nobuhiro Suetsugu, Atsushi Takai, Koji Shiraki, Makoto Shimizu, Masahito |
author_facet | Sakai, Hiroyasu Miwa, Takao Ikoma, Yoshikazu Hanai, Tatsunori Nakamura, Nobuhiko Imai, Kenji Kitagawa, Junichi Shirakami, Yohei Kanemura, Nobuhiro Suetsugu, Atsushi Takai, Koji Shiraki, Makoto Shimizu, Masahito |
author_sort | Sakai, Hiroyasu |
collection | PubMed |
description | Recently, treatments for chronic hepatitis C virus (HCV) infection have significantly improved by the development of direct-acting antiviral agents (DAAs) and almost all patients with HCV can complete antiviral treatment without apparent adverse events. Malignant lymphoma, particularly B-cell non-Hodgkin's lymphoma, is one of the extrahepatic manifestations associated with chronic HCV infection. The effectiveness of anti-HCV therapy with DAAs for B-cell non-Hodgkin's lymphoma has been demonstrated in recent reports, whereas late-onset B-cell non-Hodgkin's lymphoma after HCV eradication with DAAs has occasionally been reported. In the present study, a 77-year-old man with chronic hepatitis C and intermediate liver cancer risk received sofosbuvir-ledipasvir treatment for 12 weeks. Two months following the end of antiviral therapy, he had achieved sustained virologic response for 8 weeks. However, the patient occasionally found swelling of the right cervical lymph nodes without any subjective symptoms. Lymph node biopsy revealed diffuse large B-cell lymphoma and whole-body (18)F-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography showed increased FDG uptake in the right cervical, right submandibular, mediastinal and mesenteric lymph nodes. The patient received six courses of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy and achieved complete response at 8 months after chemotherapy initiation. Thus, the development of lymphoid malignancies may arise, even after HCV eradication with DAAs. Therefore, clinicians should be aware of such risks during and after antiviral treatment with DAAs. |
format | Online Article Text |
id | pubmed-7391802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-73918022020-08-03 Development of diffuse large B-cell lymphoma after sofosbuvir-ledipasvir treatment for chronic hepatitis C: A case report and literature review Sakai, Hiroyasu Miwa, Takao Ikoma, Yoshikazu Hanai, Tatsunori Nakamura, Nobuhiko Imai, Kenji Kitagawa, Junichi Shirakami, Yohei Kanemura, Nobuhiro Suetsugu, Atsushi Takai, Koji Shiraki, Makoto Shimizu, Masahito Mol Clin Oncol Articles Recently, treatments for chronic hepatitis C virus (HCV) infection have significantly improved by the development of direct-acting antiviral agents (DAAs) and almost all patients with HCV can complete antiviral treatment without apparent adverse events. Malignant lymphoma, particularly B-cell non-Hodgkin's lymphoma, is one of the extrahepatic manifestations associated with chronic HCV infection. The effectiveness of anti-HCV therapy with DAAs for B-cell non-Hodgkin's lymphoma has been demonstrated in recent reports, whereas late-onset B-cell non-Hodgkin's lymphoma after HCV eradication with DAAs has occasionally been reported. In the present study, a 77-year-old man with chronic hepatitis C and intermediate liver cancer risk received sofosbuvir-ledipasvir treatment for 12 weeks. Two months following the end of antiviral therapy, he had achieved sustained virologic response for 8 weeks. However, the patient occasionally found swelling of the right cervical lymph nodes without any subjective symptoms. Lymph node biopsy revealed diffuse large B-cell lymphoma and whole-body (18)F-fluorodeoxyglucose (FDG) positron emission tomography with computed tomography showed increased FDG uptake in the right cervical, right submandibular, mediastinal and mesenteric lymph nodes. The patient received six courses of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy and achieved complete response at 8 months after chemotherapy initiation. Thus, the development of lymphoid malignancies may arise, even after HCV eradication with DAAs. Therefore, clinicians should be aware of such risks during and after antiviral treatment with DAAs. D.A. Spandidos 2020-09 2020-06-16 /pmc/articles/PMC7391802/ /pubmed/32754315 http://dx.doi.org/10.3892/mco.2020.2071 Text en Copyright: © Sakai et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Sakai, Hiroyasu Miwa, Takao Ikoma, Yoshikazu Hanai, Tatsunori Nakamura, Nobuhiko Imai, Kenji Kitagawa, Junichi Shirakami, Yohei Kanemura, Nobuhiro Suetsugu, Atsushi Takai, Koji Shiraki, Makoto Shimizu, Masahito Development of diffuse large B-cell lymphoma after sofosbuvir-ledipasvir treatment for chronic hepatitis C: A case report and literature review |
title | Development of diffuse large B-cell lymphoma after sofosbuvir-ledipasvir treatment for chronic hepatitis C: A case report and literature review |
title_full | Development of diffuse large B-cell lymphoma after sofosbuvir-ledipasvir treatment for chronic hepatitis C: A case report and literature review |
title_fullStr | Development of diffuse large B-cell lymphoma after sofosbuvir-ledipasvir treatment for chronic hepatitis C: A case report and literature review |
title_full_unstemmed | Development of diffuse large B-cell lymphoma after sofosbuvir-ledipasvir treatment for chronic hepatitis C: A case report and literature review |
title_short | Development of diffuse large B-cell lymphoma after sofosbuvir-ledipasvir treatment for chronic hepatitis C: A case report and literature review |
title_sort | development of diffuse large b-cell lymphoma after sofosbuvir-ledipasvir treatment for chronic hepatitis c: a case report and literature review |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391802/ https://www.ncbi.nlm.nih.gov/pubmed/32754315 http://dx.doi.org/10.3892/mco.2020.2071 |
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