Successful growth of fresh retinoblastoma cells in chorioallantoic membrane

The authors developed a retinoblastoma model using fresh harvested cells from an enucleated eye that were transplanted in chick embryos (chorioallantoic membrane model). The transplanted embryos were treated with escalating doses of Melphalan. This exploratory model was developed with the goal of te...

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Autores principales: Fialho, Silvia L., Silvestrini, Bárbara R., Vieira, Juliana, Paiva, Mayara R. B., Silva, Luciana M., Chahud, Fernando, Silva-Cunha, Armando, Correa, Zelia M., Jorge, Rodrigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391810/
https://www.ncbi.nlm.nih.gov/pubmed/32760596
http://dx.doi.org/10.1186/s40942-020-00236-x
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author Fialho, Silvia L.
Silvestrini, Bárbara R.
Vieira, Juliana
Paiva, Mayara R. B.
Silva, Luciana M.
Chahud, Fernando
Silva-Cunha, Armando
Correa, Zelia M.
Jorge, Rodrigo
author_facet Fialho, Silvia L.
Silvestrini, Bárbara R.
Vieira, Juliana
Paiva, Mayara R. B.
Silva, Luciana M.
Chahud, Fernando
Silva-Cunha, Armando
Correa, Zelia M.
Jorge, Rodrigo
author_sort Fialho, Silvia L.
collection PubMed
description The authors developed a retinoblastoma model using fresh harvested cells from an enucleated eye that were transplanted in chick embryos (chorioallantoic membrane model). The transplanted embryos were treated with escalating doses of Melphalan. This exploratory model was developed with the goal of testing drug sensitivity. Our findings suggest this tumor model could be employed to personalize treatment for patients with retinoblastoma, especially those with bilateral and more refractory disease.
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spelling pubmed-73918102020-08-04 Successful growth of fresh retinoblastoma cells in chorioallantoic membrane Fialho, Silvia L. Silvestrini, Bárbara R. Vieira, Juliana Paiva, Mayara R. B. Silva, Luciana M. Chahud, Fernando Silva-Cunha, Armando Correa, Zelia M. Jorge, Rodrigo Int J Retina Vitreous Letter to the Editor The authors developed a retinoblastoma model using fresh harvested cells from an enucleated eye that were transplanted in chick embryos (chorioallantoic membrane model). The transplanted embryos were treated with escalating doses of Melphalan. This exploratory model was developed with the goal of testing drug sensitivity. Our findings suggest this tumor model could be employed to personalize treatment for patients with retinoblastoma, especially those with bilateral and more refractory disease. BioMed Central 2020-07-29 /pmc/articles/PMC7391810/ /pubmed/32760596 http://dx.doi.org/10.1186/s40942-020-00236-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Fialho, Silvia L.
Silvestrini, Bárbara R.
Vieira, Juliana
Paiva, Mayara R. B.
Silva, Luciana M.
Chahud, Fernando
Silva-Cunha, Armando
Correa, Zelia M.
Jorge, Rodrigo
Successful growth of fresh retinoblastoma cells in chorioallantoic membrane
title Successful growth of fresh retinoblastoma cells in chorioallantoic membrane
title_full Successful growth of fresh retinoblastoma cells in chorioallantoic membrane
title_fullStr Successful growth of fresh retinoblastoma cells in chorioallantoic membrane
title_full_unstemmed Successful growth of fresh retinoblastoma cells in chorioallantoic membrane
title_short Successful growth of fresh retinoblastoma cells in chorioallantoic membrane
title_sort successful growth of fresh retinoblastoma cells in chorioallantoic membrane
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391810/
https://www.ncbi.nlm.nih.gov/pubmed/32760596
http://dx.doi.org/10.1186/s40942-020-00236-x
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