1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors

[Image: see text] The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (K(i) values ranging...

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Detalles Bibliográficos
Autores principales: Haarr, Marianne B., Lopéz, Óscar, Pejov, Ljupcho, Fernández-Bolaños, José G., Lindbäck, Emil, Sydnes, Magne O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391959/
https://www.ncbi.nlm.nih.gov/pubmed/32743229
http://dx.doi.org/10.1021/acsomega.0c02466
Descripción
Sumario:[Image: see text] The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (K(i) values ranging from 0.23 to 1.4 μM).

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