1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors

[Image: see text] The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (K(i) values ranging...

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Autores principales: Haarr, Marianne B., Lopéz, Óscar, Pejov, Ljupcho, Fernández-Bolaños, José G., Lindbäck, Emil, Sydnes, Magne O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391959/
https://www.ncbi.nlm.nih.gov/pubmed/32743229
http://dx.doi.org/10.1021/acsomega.0c02466
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author Haarr, Marianne B.
Lopéz, Óscar
Pejov, Ljupcho
Fernández-Bolaños, José G.
Lindbäck, Emil
Sydnes, Magne O.
author_facet Haarr, Marianne B.
Lopéz, Óscar
Pejov, Ljupcho
Fernández-Bolaños, José G.
Lindbäck, Emil
Sydnes, Magne O.
author_sort Haarr, Marianne B.
collection PubMed
description [Image: see text] The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (K(i) values ranging from 0.23 to 1.4 μM).
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spelling pubmed-73919592020-07-31 1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors Haarr, Marianne B. Lopéz, Óscar Pejov, Ljupcho Fernández-Bolaños, José G. Lindbäck, Emil Sydnes, Magne O. ACS Omega [Image: see text] The synthesis of two polyhydroxylated pyrrolidines as 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) analogues bearing a hydrazide moiety is described. The DAB analogues act as selective and potent inhibitors of α-mannosidase in the submicromolar concentration ranges (K(i) values ranging from 0.23 to 1.4 μM). American Chemical Society 2020-07-15 /pmc/articles/PMC7391959/ /pubmed/32743229 http://dx.doi.org/10.1021/acsomega.0c02466 Text en Copyright © 2020 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Haarr, Marianne B.
Lopéz, Óscar
Pejov, Ljupcho
Fernández-Bolaños, José G.
Lindbäck, Emil
Sydnes, Magne O.
1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
title 1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
title_full 1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
title_fullStr 1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
title_full_unstemmed 1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
title_short 1,4-Dideoxy-1,4-imino-d-arabinitol (DAB) Analogues Possessing a Hydrazide Imide Moiety as Potent and Selective α-Mannosidase Inhibitors
title_sort 1,4-dideoxy-1,4-imino-d-arabinitol (dab) analogues possessing a hydrazide imide moiety as potent and selective α-mannosidase inhibitors
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391959/
https://www.ncbi.nlm.nih.gov/pubmed/32743229
http://dx.doi.org/10.1021/acsomega.0c02466
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