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Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis

Rationale: Endophthalmitis, which is one of the severest complications of cataract surgeries, can seriously threaten vision and even lead to irreversible blindness owing to its complicated microenvironment, including both local bacterial infection and severe inflammation. It is urgent to develop a c...

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Autores principales: Ye, Yang, He, Jian, Qiao, Yue, Qi, Yuchen, Zhang, Hongbo, Santos, Hélder A., Zhong, Danni, Li, Wanlin, Hua, Shiyuan, Wang, Wei, Grzybowski, Andrzej, Yao, Ke, Zhou, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392004/
https://www.ncbi.nlm.nih.gov/pubmed/32754262
http://dx.doi.org/10.7150/thno.46895
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author Ye, Yang
He, Jian
Qiao, Yue
Qi, Yuchen
Zhang, Hongbo
Santos, Hélder A.
Zhong, Danni
Li, Wanlin
Hua, Shiyuan
Wang, Wei
Grzybowski, Andrzej
Yao, Ke
Zhou, Min
author_facet Ye, Yang
He, Jian
Qiao, Yue
Qi, Yuchen
Zhang, Hongbo
Santos, Hélder A.
Zhong, Danni
Li, Wanlin
Hua, Shiyuan
Wang, Wei
Grzybowski, Andrzej
Yao, Ke
Zhou, Min
author_sort Ye, Yang
collection PubMed
description Rationale: Endophthalmitis, which is one of the severest complications of cataract surgeries, can seriously threaten vision and even lead to irreversible blindness owing to its complicated microenvironment, including both local bacterial infection and severe inflammation. It is urgent to develop a comprehensive treatment for both anti-bacterial and anti-inflammatory effects. Methods: Herein, we developed AuAgCu(2)O-bromfenac sodium nanoparticles (AuAgCu(2)O-BS NPs), which was designed to combine anti-bacterial and anti-inflammatory effects for integrated therapy of endophthalmitis after cataract surgery. The AuAgCu(2)O-BS NPs could eradicate methicillin-resistant Staphylococcus aureus (MRSA) bacterial strain relied on their photodynamic effects and the release of metal ions (Ag(+) and Cu(+)) by the hollow AuAgCu(2)O nanostructures mediated mild photothermal effects. The anti-inflammatory drug, bromfenac sodium, released from the nanoparticles were able to significantly reduce the local inflammation of the endophthalmitis and promote tissue rehabilitation. In vivo bacterial elimination and anti-inflammation were confirmed by a postcataract endophthalmitis rabbit model. Results: Excellent antibacterial ability of AuAgCu(2)O-BS NPs was verified both in vitro and in vivo. Ophthalmological clinical observation and pathologic histology analysis showed prominent treatment of inflammatory reaction. Importantly, the mild temperature photothermal effect not only promoted the release of metal ions and bromfenac sodium but also avoided the thermal damage of the surrounding tissues, which was more suitable for the practical application of ophthalmology due to the complex structure of the eyeball. Moreover, superior biocompatibility was approved by the preliminary toxicity investigations, including low cytotoxicity, negligible damage to major organs, and stable intraocular pressure. Conclusions: Our studies of nanosystem provide a promising synergic therapeutic strategy for postcataract endophthalmitis treatment with favorable prognosis and promise in clinical translations.
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spelling pubmed-73920042020-08-03 Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis Ye, Yang He, Jian Qiao, Yue Qi, Yuchen Zhang, Hongbo Santos, Hélder A. Zhong, Danni Li, Wanlin Hua, Shiyuan Wang, Wei Grzybowski, Andrzej Yao, Ke Zhou, Min Theranostics Research Paper Rationale: Endophthalmitis, which is one of the severest complications of cataract surgeries, can seriously threaten vision and even lead to irreversible blindness owing to its complicated microenvironment, including both local bacterial infection and severe inflammation. It is urgent to develop a comprehensive treatment for both anti-bacterial and anti-inflammatory effects. Methods: Herein, we developed AuAgCu(2)O-bromfenac sodium nanoparticles (AuAgCu(2)O-BS NPs), which was designed to combine anti-bacterial and anti-inflammatory effects for integrated therapy of endophthalmitis after cataract surgery. The AuAgCu(2)O-BS NPs could eradicate methicillin-resistant Staphylococcus aureus (MRSA) bacterial strain relied on their photodynamic effects and the release of metal ions (Ag(+) and Cu(+)) by the hollow AuAgCu(2)O nanostructures mediated mild photothermal effects. The anti-inflammatory drug, bromfenac sodium, released from the nanoparticles were able to significantly reduce the local inflammation of the endophthalmitis and promote tissue rehabilitation. In vivo bacterial elimination and anti-inflammation were confirmed by a postcataract endophthalmitis rabbit model. Results: Excellent antibacterial ability of AuAgCu(2)O-BS NPs was verified both in vitro and in vivo. Ophthalmological clinical observation and pathologic histology analysis showed prominent treatment of inflammatory reaction. Importantly, the mild temperature photothermal effect not only promoted the release of metal ions and bromfenac sodium but also avoided the thermal damage of the surrounding tissues, which was more suitable for the practical application of ophthalmology due to the complex structure of the eyeball. Moreover, superior biocompatibility was approved by the preliminary toxicity investigations, including low cytotoxicity, negligible damage to major organs, and stable intraocular pressure. Conclusions: Our studies of nanosystem provide a promising synergic therapeutic strategy for postcataract endophthalmitis treatment with favorable prognosis and promise in clinical translations. Ivyspring International Publisher 2020-07-09 /pmc/articles/PMC7392004/ /pubmed/32754262 http://dx.doi.org/10.7150/thno.46895 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Ye, Yang
He, Jian
Qiao, Yue
Qi, Yuchen
Zhang, Hongbo
Santos, Hélder A.
Zhong, Danni
Li, Wanlin
Hua, Shiyuan
Wang, Wei
Grzybowski, Andrzej
Yao, Ke
Zhou, Min
Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis
title Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis
title_full Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis
title_fullStr Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis
title_full_unstemmed Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis
title_short Mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis
title_sort mild temperature photothermal assisted anti-bacterial and anti-inflammatory nanosystem for synergistic treatment of post-cataract surgery endophthalmitis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392004/
https://www.ncbi.nlm.nih.gov/pubmed/32754262
http://dx.doi.org/10.7150/thno.46895
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