MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma

Mutations in isocitrate dehydrogenase 1 (IDH1mut) are reported in 70-90% of low-grade gliomas and secondary glioblastomas. IDH1mut catalyzes the reduction of α-ketoglutarate (α-KG) to 2-hydroxyglutarate (2-HG), an oncometabolite which drives tumorigenesis. Inhibition of IDH1mut is therefore an emerg...

Descripción completa

Detalles Bibliográficos
Autores principales: Molloy, Abigail R, Najac, Chloé, Viswanath, Pavithra, Lakhani, Aliya, Subramani, Elavarasan, Batsios, Georgios, Radoul, Marina, Gillespie, Anne Marie, Pieper, Russell O, Ronen, Sabrina M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392019/
https://www.ncbi.nlm.nih.gov/pubmed/32754276
http://dx.doi.org/10.7150/thno.47317

Ejemplares similares

Ejemplares similares