Broadening our understanding of the genetics of Juvenile Idiopathic Arthritis (JIA): Interrogation of three dimensional chromatin structures and genetic regulatory elements within JIA-associated risk loci

OBJECTIVE: The risk loci for juvenile idiopathic arthritis (JIA) consist of extended haplotypes that include functional elements in addition to canonical coding genes. As with most autoimmune diseases, the risk haplotypes for JIA are highly enriched for H3K4me1/H3K27ac histone marks, epigenetic sign...

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Detalles Bibliográficos
Autores principales: Jiang, Kaiyu, Kessler, Haeja, Park, Yungki, Sudman, Marc, Thompson, Susan D., Jarvis, James N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392255/
https://www.ncbi.nlm.nih.gov/pubmed/32730263
http://dx.doi.org/10.1371/journal.pone.0235857

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