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PHRF1 promotes migration and invasion by modulating ZEB1 expression

PHRF1 (PHD and RING finger domain-containing protein 1) suppresses acute promyelocytic leukemia (APL) by promoting TGIF (TG-interacting factor) ubiquitination, while the PML-RARα protein interferes with PHRF1-mediated TGIF breakdown to facilitate APL. Beyond its role in APL tumorigenesis, PHRF1 cont...

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Detalles Bibliográficos
Autores principales:	Lee, Jin-Yu, Fan, Chih-Chen, Chou, Nai-Lin, Lin, Hung-Wei, Chang, Mau-Sun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392320/ https://www.ncbi.nlm.nih.gov/pubmed/32730336 http://dx.doi.org/10.1371/journal.pone.0236876

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