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Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections
Malaria caused by Plasmodium vivax is a highly prevalent infection world-wide, that was previously considered mild, but complications such as anemia have been highly reported in the past years. In mice models of malaria, anti-phosphatidylserine (anti-PS) autoantibodies, produced by atypical B-cells,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392348/ https://www.ncbi.nlm.nih.gov/pubmed/32687495 http://dx.doi.org/10.1371/journal.pntd.0008466 |
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author | Rivera-Correa, Juan Yasnot-Acosta, Maria Fernanda Tovar, Nubia Catalina Velasco-Pareja, María Camila Easton, Alice Rodriguez, Ana |
author_facet | Rivera-Correa, Juan Yasnot-Acosta, Maria Fernanda Tovar, Nubia Catalina Velasco-Pareja, María Camila Easton, Alice Rodriguez, Ana |
author_sort | Rivera-Correa, Juan |
collection | PubMed |
description | Malaria caused by Plasmodium vivax is a highly prevalent infection world-wide, that was previously considered mild, but complications such as anemia have been highly reported in the past years. In mice models of malaria, anti-phosphatidylserine (anti-PS) autoantibodies, produced by atypical B-cells, bind to uninfected erythrocytes and contribute to anemia. In human patients with P. falciparum malaria, the levels of anti-PS, atypical B-cells and anemia are strongly correlated to each other. In this study, we focused on assessing the relationship between autoantibodies, different B-cell populations and hemoglobin levels in two different cohorts of P. vivax patients from Colombia, South America. In a first longitudinal cohort, our results show a strong inverse correlation between different IgG autoantibodies tested (anti-PS, anti-DNA and anti-erythrocyte) and atypical memory B-cells (atMBCs) with hemoglobin in both P. vivax and P. falciparum patients over time. In a second cross-sectional cohort, we observed a stronger relation between hemoglobin levels, atMBCs and autoantibodies in complicated P. vivax patients compared to uncomplicated ones. Altogether, these data constitute the first evidence of autoimmunity associating with anemia and complicated P. vivax infections, suggesting a role for its etiology through the expansion of autoantibody-secreting atMBCs. |
format | Online Article Text |
id | pubmed-7392348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-73923482020-08-12 Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections Rivera-Correa, Juan Yasnot-Acosta, Maria Fernanda Tovar, Nubia Catalina Velasco-Pareja, María Camila Easton, Alice Rodriguez, Ana PLoS Negl Trop Dis Research Article Malaria caused by Plasmodium vivax is a highly prevalent infection world-wide, that was previously considered mild, but complications such as anemia have been highly reported in the past years. In mice models of malaria, anti-phosphatidylserine (anti-PS) autoantibodies, produced by atypical B-cells, bind to uninfected erythrocytes and contribute to anemia. In human patients with P. falciparum malaria, the levels of anti-PS, atypical B-cells and anemia are strongly correlated to each other. In this study, we focused on assessing the relationship between autoantibodies, different B-cell populations and hemoglobin levels in two different cohorts of P. vivax patients from Colombia, South America. In a first longitudinal cohort, our results show a strong inverse correlation between different IgG autoantibodies tested (anti-PS, anti-DNA and anti-erythrocyte) and atypical memory B-cells (atMBCs) with hemoglobin in both P. vivax and P. falciparum patients over time. In a second cross-sectional cohort, we observed a stronger relation between hemoglobin levels, atMBCs and autoantibodies in complicated P. vivax patients compared to uncomplicated ones. Altogether, these data constitute the first evidence of autoimmunity associating with anemia and complicated P. vivax infections, suggesting a role for its etiology through the expansion of autoantibody-secreting atMBCs. Public Library of Science 2020-07-20 /pmc/articles/PMC7392348/ /pubmed/32687495 http://dx.doi.org/10.1371/journal.pntd.0008466 Text en © 2020 Rivera-Correa et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Rivera-Correa, Juan Yasnot-Acosta, Maria Fernanda Tovar, Nubia Catalina Velasco-Pareja, María Camila Easton, Alice Rodriguez, Ana Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections |
title | Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections |
title_full | Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections |
title_fullStr | Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections |
title_full_unstemmed | Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections |
title_short | Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections |
title_sort | atypical memory b-cells and autoantibodies correlate with anemia during plasmodium vivax complicated infections |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392348/ https://www.ncbi.nlm.nih.gov/pubmed/32687495 http://dx.doi.org/10.1371/journal.pntd.0008466 |
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