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Characterizing Norovirus Transmission from Outbreak Data, United States

Norovirus is the leading cause of acute gastroenteritis outbreaks in the United States. We estimated the basic (R(0)) and effective (R(e)) reproduction numbers for 7,094 norovirus outbreaks reported to the National Outbreak Reporting System (NORS) during 2009–2017 and used regression models to asses...

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Autores principales: Steele, Molly K., Wikswo, Mary E., Hall, Aron J., Koelle, Katia, Handel, Andreas, Levy, Karen, Waller, Lance A., Lopman, Ben A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392428/
https://www.ncbi.nlm.nih.gov/pubmed/32687043
http://dx.doi.org/10.3201/eid2608.191537
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author Steele, Molly K.
Wikswo, Mary E.
Hall, Aron J.
Koelle, Katia
Handel, Andreas
Levy, Karen
Waller, Lance A.
Lopman, Ben A.
author_facet Steele, Molly K.
Wikswo, Mary E.
Hall, Aron J.
Koelle, Katia
Handel, Andreas
Levy, Karen
Waller, Lance A.
Lopman, Ben A.
author_sort Steele, Molly K.
collection PubMed
description Norovirus is the leading cause of acute gastroenteritis outbreaks in the United States. We estimated the basic (R(0)) and effective (R(e)) reproduction numbers for 7,094 norovirus outbreaks reported to the National Outbreak Reporting System (NORS) during 2009–2017 and used regression models to assess whether transmission varied by outbreak setting. The median R(0) was 2.75 (interquartile range [IQR] 2.38–3.65), and median R(e) was 1.29 (IQR 1.12–1.74). Long-term care and assisted living facilities had an R(0) of 3.35 (95% CI 3.26–3.45), but R(0) did not differ substantially for outbreaks in other settings, except for outbreaks in schools, colleges, and universities, which had an R(0) of 2.92 (95% CI 2.82–3.03). Seasonally, R(0) was lowest (3.11 [95% CI 2.97–3.25]) in summer and peaked in fall and winter. Overall, we saw little variability in transmission across different outbreaks settings in the United States.
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spelling pubmed-73924282020-08-06 Characterizing Norovirus Transmission from Outbreak Data, United States Steele, Molly K. Wikswo, Mary E. Hall, Aron J. Koelle, Katia Handel, Andreas Levy, Karen Waller, Lance A. Lopman, Ben A. Emerg Infect Dis Research Norovirus is the leading cause of acute gastroenteritis outbreaks in the United States. We estimated the basic (R(0)) and effective (R(e)) reproduction numbers for 7,094 norovirus outbreaks reported to the National Outbreak Reporting System (NORS) during 2009–2017 and used regression models to assess whether transmission varied by outbreak setting. The median R(0) was 2.75 (interquartile range [IQR] 2.38–3.65), and median R(e) was 1.29 (IQR 1.12–1.74). Long-term care and assisted living facilities had an R(0) of 3.35 (95% CI 3.26–3.45), but R(0) did not differ substantially for outbreaks in other settings, except for outbreaks in schools, colleges, and universities, which had an R(0) of 2.92 (95% CI 2.82–3.03). Seasonally, R(0) was lowest (3.11 [95% CI 2.97–3.25]) in summer and peaked in fall and winter. Overall, we saw little variability in transmission across different outbreaks settings in the United States. Centers for Disease Control and Prevention 2020-08 /pmc/articles/PMC7392428/ /pubmed/32687043 http://dx.doi.org/10.3201/eid2608.191537 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Steele, Molly K.
Wikswo, Mary E.
Hall, Aron J.
Koelle, Katia
Handel, Andreas
Levy, Karen
Waller, Lance A.
Lopman, Ben A.
Characterizing Norovirus Transmission from Outbreak Data, United States
title Characterizing Norovirus Transmission from Outbreak Data, United States
title_full Characterizing Norovirus Transmission from Outbreak Data, United States
title_fullStr Characterizing Norovirus Transmission from Outbreak Data, United States
title_full_unstemmed Characterizing Norovirus Transmission from Outbreak Data, United States
title_short Characterizing Norovirus Transmission from Outbreak Data, United States
title_sort characterizing norovirus transmission from outbreak data, united states
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392428/
https://www.ncbi.nlm.nih.gov/pubmed/32687043
http://dx.doi.org/10.3201/eid2608.191537
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