Cargando…

Antibiotic fidaxomicin is an RdRp inhibitor as a potential new therapeutic agent against Zika virus

BACKGROUND: Zika virus (ZIKV) infection is a global health problem, and its complications, including congenital Zika syndrome and Guillain-Barré syndrome, constitute a continued threat to humans. Unfortunately, effective therapeutics against ZIKV infection are not available thus far. METHODS: We scr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yuan, Jie, Yu, Jianchen, Huang, Yun, He, Zhenjian, Luo, Jia, Wu, Yun, Zheng, Yingchun, Wu, Jueheng, Zhu, Xun, Wang, Haihe, Li, Mengfeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392643/ https://www.ncbi.nlm.nih.gov/pubmed/32731873 http://dx.doi.org/10.1186/s12916-020-01663-1

Ejemplares similares

RdRp or RT, That is the Question
por: Peyambari, Mahtab, et al.
Publicado: (2021)

Snapshots of a Non-Canonical RdRP in Action
por: Ferrero, Diego S., et al.
Publicado: (2021)

Aging correlates with lower threshold cycle values for RdRP/RdRP+S genes during molecular detection of SARS-CoV-2
por: Mikuła-Pietrasik, Justyna, et al.
Publicado: (2021)

In silico investigation to identify potential small molecule inhibitors of the RNA-dependent RNA polymerase (RdRp) nidovirus RdRp-associated nucleotidyltransferase domain
por: Pitsillou, Eleni, et al.
Publicado: (2021)

Inhibition of HEV Replication by FDA-Approved RdRp Inhibitors
por: Hooda, Preeti, et al.
Publicado: (2023)

Evaluation of potential anti-RNA-dependent RNA polymerase (RdRP) drugs against the newly emerged model of COVID-19 RdRP using computational methods
por: Poustforoosh, Alireza, et al.
Publicado: (2021)

SARS-CoV-2 RdRp Inhibitors Selected from a Cell-Based SARS-CoV-2 RdRp Activity Assay System
por: Min, Jung Sun, et al.
Publicado: (2021)

RdRp inhibitors and COVID-19: Is molnupiravir a good option?
por: Hashemian, Seyed Mohammad Reza, et al.
Publicado: (2022)

Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity
por: Painter, Meghan M., et al.
Publicado: (2015)

RdRp mutations are associated with SARS-CoV-2 genome evolution
por: Eskier, Doğa, et al.
Publicado: (2020)

The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp
por: Gurung, Arun Bahadur, et al.
Publicado: (2021)

RdRp-based sensitive taxonomic classification of RNA viruses for metagenomic data
por: Tang, Xubo, et al.
Publicado: (2022)

Designing an effective therapeutic siRNA to silence RdRp gene of SARS-CoV-2
por: Shawan, Mohammad Mahfuz Ali Khan, et al.
Publicado: (2021)

Analysis of the codon usage pattern of the RdRP gene of mycovirus infecting Aspergillus spp.
por: Je, Mikyung, et al.
Publicado: (2019)

Targeting the RdRp of Emerging RNA Viruses: The Structure-Based Drug Design Challenge
por: Picarazzi, Francesca, et al.
Publicado: (2020)

RNA-dependent RNA polymerase (RdRp) natural antiviral inhibitors: a review
por: Leite, Daniela Regina Buch, et al.
Publicado: (2022)

RNA‐dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID‐19
por: Machitani, Mitsuhiro, et al.
Publicado: (2020)

Mechanistic insight on the remdesivir binding to RNA-Dependent RNA polymerase (RdRp) of SARS-cov-2
por: Arba, Muhammad, et al.
Publicado: (2021)

Azelnidipine Exhibits In Vitro and In Vivo Antiviral Effects against Flavivirus Infections by Targeting the Viral RdRp
por: Wang, Zhuang, et al.
Publicado: (2022)

Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp)
por: Wu, Yifei, et al.
Publicado: (2021)

Discovery of divided RdRp sequences and a hitherto unknown genomic complexity in fungal viruses
por: Chiba, Yuto, et al.
Publicado: (2020)

In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation
por: Bao, Keyan, et al.
Publicado: (2022)

Identification of RNA Virus–Derived RdRp Sequences in Publicly Available Transcriptomic Data Sets
por: Olendraite, Ingrida, et al.
Publicado: (2023)

Repurposing of Doramectin as a New Anti-Zika Virus Agent
por: Zhu, Yujia, et al.
Publicado: (2023)

Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases
por: Riccio, Federica, et al.
Publicado: (2019)

RNA-dependent RNA polymerase (RdRp) inhibitors: The current landscape and repurposing for the COVID-19 pandemic
por: Tian, Lei, et al.
Publicado: (2021)

Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides
por: Wang, Bing, et al.
Publicado: (2021)

Erratum: Discovery of divided RdRp sequences and a hitherto unknown genomic complexity in fungal viruses
por: Chiba, Yuto, et al.
Publicado: (2021)

A hypothesis on designing strategy of effective RdRp inhibitors for the treatment of SARS-CoV-2
por: Chaube, Udit, et al.
Publicado: (2022)

Design, Synthesis, Evaluation and Molecular Dynamics Simulation of Dengue Virus NS5-RdRp Inhibitors
por: Zong, Keli, et al.
Publicado: (2023)

In Silico Exploration of Phytoconstituents From Phyllanthus emblica and Aegle marmelos as Potential Therapeutics Against SARS-CoV-2 RdRp
por: Pandey, Khushboo, et al.
Publicado: (2021)

SARS-CoV-2 RNA Dependent RNA polymerase (RdRp) – A drug repurposing study
por: Ahmad, Jamshaid, et al.
Publicado: (2020)

Different selection dynamics of S and RdRp between SARS-CoV-2 genomes with and without the dominant mutations
por: Koçhan, Necla, et al.
Publicado: (2021)

Real-time PCR Ct value in SARS-CoV-2 detection: RdRp or N gene?
por: Abbasi, Hamidreza, et al.
Publicado: (2021)

Hybridization chain reaction circuit-based electrochemiluminescent biosensor for SARS-cov-2 RdRp gene assay
por: Zhang, Kai, et al.
Publicado: (2022)

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors
por: Gao, Shenghua, et al.
Publicado: (2022)

Composition of naturally occurring compounds decreases activity of Omicron and SARS-CoV-2 RdRp complex
por: Goc, Anna, et al.
Publicado: (2022)

RdRp-scan: A bioinformatic resource to identify and annotate divergent RNA viruses in metagenomic sequence data
por: Charon, Justine, et al.
Publicado: (2022)

Antiviral effects of the fused tricyclic derivatives of indoline and imidazolidinone on ZIKV infection and RdRp activities of ZIKV and DENV
por: Zhou, Guang-Feng, et al.
Publicado: (2023)

Design, synthesis, docking, and biochemical characterization of non-nucleoside SARS-CoV-2 RdRp inhibitors
por: Brindani, Nicoletta, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4jfm96vv59htm3t4gff3sgq3ik