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The adipokine fatty-acid binding protein 4 and cardiac remodeling
BACKGROUND: Previous publications about the association between fatty-acid binding protein 4 (FABP4) and cardiac remodeling have reported different, both beneficial and harmful, associations. Aim of the present investigation was to evaluate the association of FABP4 with parameters of myocardial remo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392717/ https://www.ncbi.nlm.nih.gov/pubmed/32727561 http://dx.doi.org/10.1186/s12933-020-01080-x |
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author | von Jeinsen, Beatrice Ritzen, Lisa Vietheer, Julia Unbehaun, Claudia Weferling, Maren Liebetrau, Christoph Hamm, Christian W. Rolf, Andreas Keller, Till |
author_facet | von Jeinsen, Beatrice Ritzen, Lisa Vietheer, Julia Unbehaun, Claudia Weferling, Maren Liebetrau, Christoph Hamm, Christian W. Rolf, Andreas Keller, Till |
author_sort | von Jeinsen, Beatrice |
collection | PubMed |
description | BACKGROUND: Previous publications about the association between fatty-acid binding protein 4 (FABP4) and cardiac remodeling have reported different, both beneficial and harmful, associations. Aim of the present investigation was to evaluate the association of FABP4 with parameters of myocardial remodeling defined by cardiac magnetic resonance imaging (CMR). METHODS: We investigated plasma FABP4 levels in 331 patients (71% men, mean age 63±13 years) with preserved left ventricular ejection fraction (LVEF ≥ 55%) who underwent a CMR examination. We used linear cox regression to investigate associations between FABP4 and left ventricular end-diastolic diameter (LVEDD), right ventricular end-diastolic diameter (RVEDD), relative wall thickness (RWT), left ventricular mass index (LVMI), and LVEF (unadjusted and adjusted for age, sex, body mass index, cardiac biomarkers, and comorbidities). RESULTS: FABP4 levels were associated with lower LVMI and higher NT-proBNP levels in an adjusted model. The inverse association between FABP4 and LVMI was more pronounced in lower FABP4 levels, whereas the positive association between FABP4 and NT-proBNP was more pronounced in relatively high NT-proBNP levels. CONCLUSIONS: Possible beneficial and harmful associations between FABP4 and left ventricular size have been reported. Our results suggest a beneficial association with LVMI (more pronounced in lower FABP4 levels) but a harmful association with NT-proBNP (more pronounced in higher FABP4 levels). Therefore, our results might indicate a potential dose-dependent association of FABP4, but this observation needs further investigation in larger study samples. |
format | Online Article Text |
id | pubmed-7392717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-73927172020-08-04 The adipokine fatty-acid binding protein 4 and cardiac remodeling von Jeinsen, Beatrice Ritzen, Lisa Vietheer, Julia Unbehaun, Claudia Weferling, Maren Liebetrau, Christoph Hamm, Christian W. Rolf, Andreas Keller, Till Cardiovasc Diabetol Original Investigation BACKGROUND: Previous publications about the association between fatty-acid binding protein 4 (FABP4) and cardiac remodeling have reported different, both beneficial and harmful, associations. Aim of the present investigation was to evaluate the association of FABP4 with parameters of myocardial remodeling defined by cardiac magnetic resonance imaging (CMR). METHODS: We investigated plasma FABP4 levels in 331 patients (71% men, mean age 63±13 years) with preserved left ventricular ejection fraction (LVEF ≥ 55%) who underwent a CMR examination. We used linear cox regression to investigate associations between FABP4 and left ventricular end-diastolic diameter (LVEDD), right ventricular end-diastolic diameter (RVEDD), relative wall thickness (RWT), left ventricular mass index (LVMI), and LVEF (unadjusted and adjusted for age, sex, body mass index, cardiac biomarkers, and comorbidities). RESULTS: FABP4 levels were associated with lower LVMI and higher NT-proBNP levels in an adjusted model. The inverse association between FABP4 and LVMI was more pronounced in lower FABP4 levels, whereas the positive association between FABP4 and NT-proBNP was more pronounced in relatively high NT-proBNP levels. CONCLUSIONS: Possible beneficial and harmful associations between FABP4 and left ventricular size have been reported. Our results suggest a beneficial association with LVMI (more pronounced in lower FABP4 levels) but a harmful association with NT-proBNP (more pronounced in higher FABP4 levels). Therefore, our results might indicate a potential dose-dependent association of FABP4, but this observation needs further investigation in larger study samples. BioMed Central 2020-07-29 /pmc/articles/PMC7392717/ /pubmed/32727561 http://dx.doi.org/10.1186/s12933-020-01080-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Original Investigation von Jeinsen, Beatrice Ritzen, Lisa Vietheer, Julia Unbehaun, Claudia Weferling, Maren Liebetrau, Christoph Hamm, Christian W. Rolf, Andreas Keller, Till The adipokine fatty-acid binding protein 4 and cardiac remodeling |
title | The adipokine fatty-acid binding protein 4 and cardiac remodeling |
title_full | The adipokine fatty-acid binding protein 4 and cardiac remodeling |
title_fullStr | The adipokine fatty-acid binding protein 4 and cardiac remodeling |
title_full_unstemmed | The adipokine fatty-acid binding protein 4 and cardiac remodeling |
title_short | The adipokine fatty-acid binding protein 4 and cardiac remodeling |
title_sort | adipokine fatty-acid binding protein 4 and cardiac remodeling |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392717/ https://www.ncbi.nlm.nih.gov/pubmed/32727561 http://dx.doi.org/10.1186/s12933-020-01080-x |
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