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Operational Strategies for Clinical Trials in Africa
PURPOSE: In a dramatic reversal of longstanding trends, cancer now kills more Africans than malaria. Despite Africa’s growing cancer burden, individuals of African descent, notably those residing in Africa, remain drastically under-represented in cancer clinical trials. Two recent summits—the 1st Al...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Clinical Oncology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392738/ https://www.ncbi.nlm.nih.gov/pubmed/32614727 http://dx.doi.org/10.1200/JGO.19.00204 |
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author | Graef, Katy M. Okoye, Ifeoma Ohene Oti, Naomi O. Dent, Jennifer Odedina, Folakemi T. |
author_facet | Graef, Katy M. Okoye, Ifeoma Ohene Oti, Naomi O. Dent, Jennifer Odedina, Folakemi T. |
author_sort | Graef, Katy M. |
collection | PubMed |
description | PURPOSE: In a dramatic reversal of longstanding trends, cancer now kills more Africans than malaria. Despite Africa’s growing cancer burden, individuals of African descent, notably those residing in Africa, remain drastically under-represented in cancer clinical trials. Two recent summits—the 1st All Africa Clinical Trial Summit and the Operational Strategy for Clinical Trials in Nigeria Summit—convened experts from governments, the private sector, universities, and professional societies to define the barriers to Africa’s participation in multicenter clinical studies and the strategies to eliminate those impedances. METHODS: The discussions held during the two clinical trial summits were condensed into a set of 10 recommendations covering five broad categories (funding, regulation, capacity building, Africa-centric approach, and patient engagement). In this article, four programs are presented as examples of how the summits’ recommendations can be put into practice to improve Africa’s ability to attract clinical trials, in particular, cancer clinical trials. RESULTS: These example programs all leveraged a multilateral, Africa-driven approach to building Africa’s clinical trial capacity, increasing visibility of Africa’s current clinical trial capabilities and priorities, improving regulatory infrastructure and enforcement on the continent, and optimizing patient and clinician engagement strategies. CONCLUSION: The four programs are anticipated to catalyze the involvement of more African health care sites in cancer clinical trials, enroll a greater number of African patients with cancer in those trials, and, ultimately, reverse Africa’s growing cancer incidence and mortality rates. Each program acts as a blueprint for organizations—whether government, academic, or industry—seeking to address the summits’ recommendations and increase Africa’s contributions to and active participation in clinical research. |
format | Online Article Text |
id | pubmed-7392738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Society of Clinical Oncology |
record_format | MEDLINE/PubMed |
spelling | pubmed-73927382020-08-03 Operational Strategies for Clinical Trials in Africa Graef, Katy M. Okoye, Ifeoma Ohene Oti, Naomi O. Dent, Jennifer Odedina, Folakemi T. JCO Glob Oncol SPECIAL ARTICLES PURPOSE: In a dramatic reversal of longstanding trends, cancer now kills more Africans than malaria. Despite Africa’s growing cancer burden, individuals of African descent, notably those residing in Africa, remain drastically under-represented in cancer clinical trials. Two recent summits—the 1st All Africa Clinical Trial Summit and the Operational Strategy for Clinical Trials in Nigeria Summit—convened experts from governments, the private sector, universities, and professional societies to define the barriers to Africa’s participation in multicenter clinical studies and the strategies to eliminate those impedances. METHODS: The discussions held during the two clinical trial summits were condensed into a set of 10 recommendations covering five broad categories (funding, regulation, capacity building, Africa-centric approach, and patient engagement). In this article, four programs are presented as examples of how the summits’ recommendations can be put into practice to improve Africa’s ability to attract clinical trials, in particular, cancer clinical trials. RESULTS: These example programs all leveraged a multilateral, Africa-driven approach to building Africa’s clinical trial capacity, increasing visibility of Africa’s current clinical trial capabilities and priorities, improving regulatory infrastructure and enforcement on the continent, and optimizing patient and clinician engagement strategies. CONCLUSION: The four programs are anticipated to catalyze the involvement of more African health care sites in cancer clinical trials, enroll a greater number of African patients with cancer in those trials, and, ultimately, reverse Africa’s growing cancer incidence and mortality rates. Each program acts as a blueprint for organizations—whether government, academic, or industry—seeking to address the summits’ recommendations and increase Africa’s contributions to and active participation in clinical research. American Society of Clinical Oncology 2020-07-02 /pmc/articles/PMC7392738/ /pubmed/32614727 http://dx.doi.org/10.1200/JGO.19.00204 Text en © 2020 by American Society of Clinical Oncology https://creativecommons.org/licenses/by/4.0/ Licensed under the Creative Commons Attribution 4.0 License: https://creativecommons.org/licenses/by/4.0/ |
spellingShingle | SPECIAL ARTICLES Graef, Katy M. Okoye, Ifeoma Ohene Oti, Naomi O. Dent, Jennifer Odedina, Folakemi T. Operational Strategies for Clinical Trials in Africa |
title | Operational Strategies for Clinical Trials in Africa |
title_full | Operational Strategies for Clinical Trials in Africa |
title_fullStr | Operational Strategies for Clinical Trials in Africa |
title_full_unstemmed | Operational Strategies for Clinical Trials in Africa |
title_short | Operational Strategies for Clinical Trials in Africa |
title_sort | operational strategies for clinical trials in africa |
topic | SPECIAL ARTICLES |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392738/ https://www.ncbi.nlm.nih.gov/pubmed/32614727 http://dx.doi.org/10.1200/JGO.19.00204 |
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