Targeting QKI-7 in vivo restores endothelial cell function in diabetes

Vascular endothelial cell (EC) dysfunction plays a key role in diabetic complications. This study discovers significant upregulation of Quaking-7 (QKI-7) in iPS cell-derived ECs when exposed to hyperglycemia, and in human iPS-ECs from diabetic patients. QKI-7 is also highly expressed in human corona...

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Detalles Bibliográficos
Autores principales: Yang, Chunbo, Eleftheriadou, Magdalini, Kelaini, Sophia, Morrison, Thomas, González, Marta Vilà, Caines, Rachel, Edwards, Nicola, Yacoub, Andrew, Edgar, Kevin, Moez, Arya, Ivetic, Aleksandar, Zampetaki, Anna, Zeng, Lingfang, Wilkinson, Fiona L., Lois, Noemi, Stitt, Alan W., Grieve, David J., Margariti, Andriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393072/
https://www.ncbi.nlm.nih.gov/pubmed/32732889
http://dx.doi.org/10.1038/s41467-020-17468-y

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